STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway.
Animals
CCAAT-Enhancer-Binding Protein-beta
/ genetics
Cell Line, Tumor
Cell Proliferation
/ drug effects
Disease Models, Animal
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Melanocytes
/ drug effects
Melanoma
/ genetics
Mice
Microphthalmia-Associated Transcription Factor
/ genetics
Neoplasm Metastasis
STAT3 Transcription Factor
/ genetics
Signal Transduction
/ drug effects
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
19
02
2020
accepted:
24
11
2020
revised:
30
10
2020
pubmed:
17
12
2020
medline:
29
7
2021
entrez:
16
12
2020
Statut:
ppublish
Résumé
Metastatic melanoma is hallmarked by its ability of phenotype switching to more slowly proliferating, but highly invasive cells. Here, we tested the impact of signal transducer and activator of transcription 3 (STAT3) on melanoma progression in association with melanocyte inducing transcription factor (MITF) expression levels. We established a mouse melanoma model for deleting Stat3 in melanocytes with specific expression of human hyperactive NRAS
Identifiants
pubmed: 33323974
doi: 10.1038/s41388-020-01584-6
pii: 10.1038/s41388-020-01584-6
pmc: PMC7116782
mid: EMS114698
doi:
Substances chimiques
CCAAT-Enhancer-Binding Protein-beta
0
Cebpb protein, mouse
0
Microphthalmia-Associated Transcription Factor
0
Mitf protein, mouse
0
STAT3 Transcription Factor
0
Stat3 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1091-1105Subventions
Organisme : Austrian Science Fund FWF
ID : P 25336
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : F 4707
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : F 6105
Pays : Austria
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