Maturity-Onset Diabetes of the Young Identified Among Algerian Probands with Early-Onset Diabetes.
MODY
early-onset
genes
monogenic diabetes
type 1 diabetes
Journal
Diabetes, metabolic syndrome and obesity : targets and therapy
ISSN: 1178-7007
Titre abrégé: Diabetes Metab Syndr Obes
Pays: New Zealand
ID NLM: 101515585
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
07
2020
accepted:
03
11
2020
entrez:
16
12
2020
pubmed:
17
12
2020
medline:
17
12
2020
Statut:
epublish
Résumé
To investigate the prevalence of variants within selected maturity-onset diabetes of the young (MODY)-genes among Algerian patients initially diagnosed with type 1 diabetes (T1D) or type 2 diabetes (T2D), yet presenting with a MODY-like phenotype. Eight unrelated patients with early-onset diabetes (before 30 years) and six relatives with diabetes were examined by targeted re-sequencing for variants in genes known to be involved in MODY ( A total of 12 variants were identified, of which three were classified as pathogenic and one as a variant of uncertain clinical significance (VUS). Two of the pathogenic variants were found in Variants in known MODY-genes can be the cause of early-onset diabetes in Algerians diagnosed with T1D or T2D among patients presenting with a MODY-like phenotype; thus, genetic screening should be considered.
Identifiants
pubmed: 33324081
doi: 10.2147/DMSO.S269251
pii: 269251
pmc: PMC7733395
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4829-4837Informations de copyright
© 2020 Bouldjennet et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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