Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities.
COVID
acute lung injury
adenosine
adenosine deaminase
adenosine kinase
coronavirus
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
08
2020
accepted:
21
10
2020
entrez:
16
12
2020
pubmed:
17
12
2020
medline:
17
12
2020
Statut:
epublish
Résumé
The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical interventions. Crucial clinical needs are: 1) prevention of infection and spread of the virus within lung epithelia and between people, 2) attenuation of excessive lung injury in Advanced Respiratory Distress Syndrome, which develops during the end stage of the disease, and 3) prevention of thrombosis associated with SARS-CoV-2 infection. Adenosine and the key adenosine regulators adenosine deaminase (ADA), adenosine kinase (ADK), and equilibrative nucleoside transporter 1 may play a role in COVID-19 pathogenesis. Here, we highlight 1) the non-enzymatic role of ADA by which it might out-compete the virus (SARS-CoV-2) for binding to the CD26 receptor, 2) the enzymatic roles of ADK and ADA to increase adenosine levels and ameliorate Advanced Respiratory Distress Syndrome, and 3) inhibition of adenosine transporters to reduce platelet activation, thrombosis and improve COVID-19 outcomes. Depending on the stage of exposure to and infection by SARS-CoV-2, enhancing adenosine levels by targeting key adenosine regulators such as ADA, ADK and equilibrative nucleoside transporter 1 might find therapeutic use against COVID-19 and warrants further investigation.
Identifiants
pubmed: 33324223
doi: 10.3389/fphar.2020.594487
pii: 594487
pmc: PMC7726428
doi:
Types de publication
Journal Article
Langues
eng
Pagination
594487Subventions
Organisme : NINDS NIH HHS
ID : R01 NS103740
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS065957
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115458
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119000
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH100972
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105329
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA032444
Pays : United States
Informations de copyright
Copyright © 2020 Geiger, Khan, Murugan and Boison.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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