Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A.
H89
cyclic adenosine monophosphate
protein kinase A
protein kinase A inhibition
protein kinase inhibitor peptide
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
06
2020
accepted:
02
11
2020
entrez:
16
12
2020
pubmed:
17
12
2020
medline:
17
12
2020
Statut:
epublish
Résumé
The protein kinase enzyme family plays a pivotal role in almost every aspect of cellular function, including cellular metabolism, division, proliferation, transcription, movement, and survival. Protein kinase A (PKA), whose activation is triggered by cyclic adenosine monophosphate (cAMP), is widely distributed in various systems and tissues throughout the body and highly related to pathogenesis and progression of various kinds of diseases. The inhibition of PKA activation is essential for the study of PKA functions. Protein kinase inhibitor peptide (PKI) is a potent, heat-stable, and specific PKA inhibitor. It has been demonstrated that PKI can block PKA-mediated phosphorylase activation. Since then, researchers have a lot of knowledge about PKI. PKI is considered to be the most effective and specific method to inhibit PKA and is widely used in related research. In this review, we will first introduce the knowledge on the activation of PKA and mechanisms related on the inhibitory effects of PKI on PKA. Then, we will compare PKI-mediated PKA inhibition vs. several popular methods of PKA inhibition.
Identifiants
pubmed: 33324237
doi: 10.3389/fphys.2020.574030
pmc: PMC7723848
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
574030Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL140071
Pays : United States
Informations de copyright
Copyright © 2020 Liu, Ke, Zhang, Zhang and Chen.
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