Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI.
Animal model
MRI
intracranial atherosclerosis
vessel wall imaging
Journal
The neuroradiology journal
ISSN: 2385-1996
Titre abrégé: Neuroradiol J
Pays: United States
ID NLM: 101295103
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
pubmed:
17
12
2020
medline:
11
9
2021
entrez:
16
12
2020
Statut:
ppublish
Résumé
Vessel wall magnetic resonance imaging can improve the evaluation of intracranial atherosclerotic disease. However, pathological validation is needed to improve vessel wall magnetic resonance imaging techniques. Human pathology samples are not practical for such analysis, so an animal model is therefore needed. Watanabe heritable hyperlipidemic rabbits and apolipoprotein E knockout rabbits were evaluated against New Zealand white wild-type rabbits. Evaluation of intracranial arteries was performed with vessel wall magnetic resonance imaging and pathological analysis, rating the presence and severity of disease in each segment. Two-tailed Seventeen rabbits (five Watanabe heritable hyperlipidemic, four apolipoprotein E knockout and eight New Zealand white) were analysed for a total of 51 artery segments. Eleven segments (five Watanabe heritable hyperlipidemic and six apolipoprotein E knockout) demonstrated intracranial atherosclerotic disease on pathology. Disease model animals had lesions more frequently than New Zealand white animals ( Intracranial atherosclerotic disease can be reliably produced and detected using 3T vessel wall magnetic resonance imaging-compatible Watanabe heritable hyperlipidemic and ApoE rabbit models. Further analysis is needed to characterize better the development and progression of the disease to correlate tissue-validated animal findings with those in human vessel wall magnetic resonance imaging studies.
Identifiants
pubmed: 33325806
doi: 10.1177/1971400920980153
pmc: PMC8165905
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-199Subventions
Organisme : NINDS NIH HHS
ID : K23 NS105924
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127582
Pays : United States
Organisme : NIH HHS
ID : S10 OD018482
Pays : United States
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