CXCR4-Binding Positron Emission Tomography Tracers Link Monocyte Recruitment and Endothelial Injury in Murine Atherosclerosis.
Animals
Aorta, Thoracic
/ diagnostic imaging
Atherosclerosis
/ diagnostic imaging
Biomarkers
/ metabolism
Cell Line
Chemokines
/ administration & dosage
Disease Models, Animal
Endothelial Cells
/ immunology
Endothelium, Vascular
/ diagnostic imaging
Injections, Intravenous
Male
Mice, Inbred C57BL
Mice, Knockout
Mice, Knockout, ApoE
Molecular Imaging
Monocytes
/ immunology
Organometallic Compounds
/ administration & dosage
Plaque, Atherosclerotic
Positron-Emission Tomography
Predictive Value of Tests
Radiopharmaceuticals
/ administration & dosage
Receptors, CXCR4
/ genetics
atherosclerosis
endothelial cells
fluorescence
monocyte
receptor, chemokine
Journal
Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
18
12
2020
medline:
2
6
2021
entrez:
17
12
2020
Statut:
ppublish
Résumé
vMIP-II (viral macrophage inflammatory protein 2)/vCCL2 (viral chemotactic cytokine ligand 2) binds to multiple chemokine receptors, and vMIP-II-based positron emission tomography tracer ( Endothelial injury status of plaques is marked by CXCR4 expression and this injury correlates with the tendency of such plaques to recruit monocytes. Furthermore, our findings suggest positron emission tomography tracers that mark CXCR4 can be used translationally to monitor the state of plaque injury and monocyte recruitment.
Identifiants
pubmed: 33327748
doi: 10.1161/ATVBAHA.120.315053
pmc: PMC8105279
mid: NIHMS1654370
doi:
Substances chimiques
(64)Cu-DOTA-vMIP-II
0
Biomarkers
0
CXCR4 protein, mouse
0
Chemokines
0
Organometallic Compounds
0
Radiopharmaceuticals
0
Receptors, CXCR4
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
822-836Subventions
Organisme : NHLBI NIH HHS
ID : R35 HL145212
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI049653
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB025815
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007081
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP1 DK109668
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI049653
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125655
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118206
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020579
Pays : United States
Commentaires et corrections
Type : CommentIn
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