Acute pancreatitis in intraductal papillary mucinous neoplasms correlates with pancreatic volume and epithelial subtypes.

Adenocarcinoma, Mucinous Adult Aged Aged, 80 and over Carcinoma, Pancreatic Ductal / complications Contrast Media Epithelium / diagnostic imaging Female Humans Incidence Male Middle Aged Pancreas / diagnostic imaging Pancreatic Neoplasms / complications Pancreatitis / diagnostic imaging Retrospective Studies Tomography, X-Ray Computed

Acute pancreatitis IPMN Pancreatic volume

Journal

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

ISSN: 1424-3911

Titre abrégé: Pancreatology

Pays: Switzerland

ID NLM: 100966936

Informations de publication

Date de publication:
Jan 2021

Historique:

received: 17 08 2020

revised: 09 11 2020

accepted: 15 11 2020

pubmed: 18 12 2020

medline: 21 10 2021

entrez: 17 12 2020

Statut: ppublish

Résumé

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is associated with acute pancreatitis (AP) in some cases, however its causes have not been fully elucidated. We investigated the association of the incidence of AP with epithelial subtypes and pancreatic volume in IPMN. This retrospective study included 182 consecutive surgically resected IPMN patients between January 2000 and December 2018. The relationship between the incidence of AP and epithelial subtypes of IPMN and pancreatic volume was investigated. Epithelial subtypes of IPMN were classified into gastric (G type: N = 116), intestinal (I type: N = 49), pancreatobiliary (PB type: N = 14), and oncocytic types (O type: N = 3). Pancreatic volume of the contrast-enhanced computed tomography scan was measured using Ziostation2 software. Histological pancreatic parenchymal atrophy was also evaluated. AP occurred more frequently in I-types (I-type vs. G-type, 22.4% [11/49] vs 3.4% [4/116], P = 0.003) and PB-types (PB type vs. G-type, 35.7% [5/14] vs. 3.4% [4/116], P = 0.007) in comparison with G-types, which constituted the majority of the resected IPMNs. AP occurred more frequently in I-type patients with high pancreatic volumes (I-type with high pancreatic volume vs. I-type with low pancreatic volume, 37.0% [10/27] vs. 4.7% [1/21], P = 0.02). However, histological atrophy did not show an additional influence on the association between the incidence of AP and epithelial subtypes. The elevation of serum pancreatic enzymes was not significantly related to epithelial subtypes. Epithelial subtypes and the degree of pancreatic volume may be closely associated with the incidence of AP in IPMN.

Sections du résumé

BACKGROUND BACKGROUND

METHODS METHODS

This retrospective study included 182 consecutive surgically resected IPMN patients between January 2000 and December 2018. The relationship between the incidence of AP and epithelial subtypes of IPMN and pancreatic volume was investigated. Epithelial subtypes of IPMN were classified into gastric (G type: N = 116), intestinal (I type: N = 49), pancreatobiliary (PB type: N = 14), and oncocytic types (O type: N = 3). Pancreatic volume of the contrast-enhanced computed tomography scan was measured using Ziostation2 software. Histological pancreatic parenchymal atrophy was also evaluated.

RESULTS RESULTS

AP occurred more frequently in I-types (I-type vs. G-type, 22.4% [11/49] vs 3.4% [4/116], P = 0.003) and PB-types (PB type vs. G-type, 35.7% [5/14] vs. 3.4% [4/116], P = 0.007) in comparison with G-types, which constituted the majority of the resected IPMNs. AP occurred more frequently in I-type patients with high pancreatic volumes (I-type with high pancreatic volume vs. I-type with low pancreatic volume, 37.0% [10/27] vs. 4.7% [1/21], P = 0.02). However, histological atrophy did not show an additional influence on the association between the incidence of AP and epithelial subtypes. The elevation of serum pancreatic enzymes was not significantly related to epithelial subtypes.

CONCLUSION CONCLUSIONS

Epithelial subtypes and the degree of pancreatic volume may be closely associated with the incidence of AP in IPMN.

Identifiants

DOI: 10.1016/j.pan.2020.11.005 PMID: 33328127

pubmed: 33328127

pii: S1424-3903(20)30838-3

doi: 10.1016/j.pan.2020.11.005

pii:

doi:

Substances chimiques

Contrast Media 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

138-143

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of competing interest The authors have no conflicts of interest.