Synaptic plasticity rules with physiological calcium levels.
STDP
computational model
hippocampus
plasticity
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
29 12 2020
29 12 2020
Historique:
pubmed:
18
12
2020
medline:
11
2
2021
entrez:
17
12
2020
Statut:
ppublish
Résumé
Spike-timing-dependent plasticity (STDP) is considered as a primary mechanism underlying formation of new memories during learning. Despite the growing interest in activity-dependent plasticity, it is still unclear whether synaptic plasticity rules inferred from in vitro experiments are correct in physiological conditions. The abnormally high calcium concentration used in in vitro studies of STDP suggests that in vivo plasticity rules may differ significantly from in vitro experiments, especially since STDP depends strongly on calcium for induction. We therefore studied here the influence of extracellular calcium on synaptic plasticity. Using a combination of experimental (patch-clamp recording and Ca
Identifiants
pubmed: 33328274
pii: 2013663117
doi: 10.1073/pnas.2013663117
pmc: PMC7777146
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
33639-33648Subventions
Organisme : HSRD VA
ID : CDP 13-003
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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