MIRRAGGE - Minimum Information Required for Reproducible AGGregation Experiments.
amyloid
peptide
phase separation
protein
reproducible data
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
07
2020
accepted:
23
10
2020
entrez:
17
12
2020
pubmed:
18
12
2020
medline:
18
12
2020
Statut:
epublish
Résumé
Reports on phase separation and amyloid formation for multiple proteins and aggregation-prone peptides are recurrently used to explore the molecular mechanisms associated with several human diseases. The information conveyed by these reports can be used directly in translational investigation, e.g., for the design of better drug screening strategies, or be compiled in databases for benchmarking novel aggregation-predicting algorithms. Given that minute protocol variations determine different outcomes of protein aggregation assays, there is a strong urge for standardized descriptions of the different types of aggregates and the detailed methods used in their production. In an attempt to address this need, we assembled the Minimum Information Required for Reproducible Aggregation Experiments (MIRRAGGE) guidelines, considering first-principles and the established literature on protein self-assembly and aggregation. This consensus information aims to cover the major and subtle determinants of experimental reproducibility while avoiding excessive technical details that are of limited practical interest for non-specialized users. The MIRRAGGE table (template available in Supplementary Information) is useful as a guide for the design of new studies and as a checklist during submission of experimental reports for publication. Full disclosure of relevant information also enables other researchers to reproduce results correctly and facilitates systematic data deposition into curated databases.
Identifiants
pubmed: 33328883
doi: 10.3389/fnmol.2020.582488
pmc: PMC7729192
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
582488Informations de copyright
Copyright © 2020 Martins, Navarro, Silva, Pinto, Sárkány, Figueiredo, Pereira, Pinheiro, Bednarikova, Burdukiewicz, Galzitskaya, Gazova, Gomes, Pastore, Serpell, Skrabana, Smirnovas, Ziaunys, Otzen, Ventura and Macedo-Ribeiro.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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