Astrocyte-Oligodendrocyte-Microglia Crosstalk in Astrocytopathies.
Aicardi–Goutières syndrome
Alexander disease
astrocytopathies
cellular crosstalk
megalencephalic leukoencephalopathy with subcortical cysts
oculodentodigital dysplasia
vanishing white matter
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
09
2020
accepted:
16
10
2020
entrez:
17
12
2020
pubmed:
18
12
2020
medline:
18
12
2020
Statut:
epublish
Résumé
Defective astrocyte function due to a genetic mutation can have major consequences for microglia and oligodendrocyte physiology, which in turn affects the white matter integrity of the brain. This review addresses the current knowledge on shared and unique pathophysiological mechanisms of astrocytopathies, including vanishing white matter, Alexander disease, megalencephalic leukoencephalopathy with subcortical cysts, Aicardi-Goutières syndrome, and oculodentodigital dysplasia. The mechanisms of disease include protein accumulation, unbalanced secretion of extracellular matrix proteins, pro- and anti-inflammatory molecules, cytokines and chemokines by astrocytes, as well as an altered gap junctional network and a changed ionic and nutrient homeostasis. Interestingly, the extent to which astrogliosis and microgliosis are present in these astrocytopathies is highly variable. An improved understanding of astrocyte-microglia-oligodendrocyte crosstalk might ultimately lead to the identification of druggable targets for these, currently untreatable, severe conditions.
Identifiants
pubmed: 33328899
doi: 10.3389/fncel.2020.608073
pmc: PMC7710860
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
608073Informations de copyright
Copyright © 2020 de Waard and Bugiani.
Références
Ann Clin Transl Neurol. 2017 Jun 06;4(7):450-465
pubmed: 28695146
Neurosci Biobehav Rev. 2017 Jun;77:87-97
pubmed: 28279812
Mol Brain. 2019 Dec 30;12(1):116
pubmed: 31888684
Exp Neurol. 2014 Jan;251:39-46
pubmed: 24200549
Glia. 2003 Dec;44(3):283-95
pubmed: 14603469
Sci Rep. 2016 Nov 07;6:36218
pubmed: 27819278
Eur J Neurosci. 2003 Oct;18(8):2313-8
pubmed: 14622192
ACS Appl Mater Interfaces. 2019 May 1;11(17):15344-15353
pubmed: 30974942
Ann Neurol. 1984 Jan;15(1):49-54
pubmed: 6712192
Dev Med Child Neurol. 2013 Jan;55(1):46-57
pubmed: 23121296
Neurobiol Dis. 2007 Jun;26(3):532-45
pubmed: 17434314
J Neurochem. 2016 Jan;136 Suppl 1:10-7
pubmed: 25693054
J Biosci. 2018 Dec;43(5):1055-1068
pubmed: 30541963
J Neuropathol Exp Neurol. 2010 Oct;69(10):987-96
pubmed: 20838246
Am J Hum Genet. 2006 Aug;79(2):197-213
pubmed: 16826512
Trends Neurosci. 1993 May;16(5):186-92
pubmed: 7685944
Int J Biochem Cell Biol. 2010 Nov;42(11):1753-6
pubmed: 20599520
J Pediatr. 1963 Jul;63:69-75
pubmed: 13949300
Am J Pathol. 1999 May;154(5):1563-72
pubmed: 10329608
Ann Neurol. 2002 Feb;51(2):264-70
pubmed: 11835386
Brain Pathol. 2018 May;28(3):388-398
pubmed: 29740945
Cell Mol Life Sci. 2016 Nov;73(21):4101-20
pubmed: 27141937
Brain Behav. 2012 May;2(3):345-56
pubmed: 22741103
Trends Immunol. 2007 Mar;28(3):138-45
pubmed: 17276138
Eur J Med Genet. 2015 Feb;58(2):71-4
pubmed: 25497041
J Cell Sci. 2013 Jul 1;126(Pt 13):2857-66
pubmed: 23606748
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Am J Hum Genet. 2007 Oct;81(4):713-25
pubmed: 17846997
Prog Neurobiol. 2008 Dec 11;86(4):342-67
pubmed: 18948166
Brain Dev. 2005 Apr;27(3):201-6
pubmed: 15737701
Glia. 2007 Oct;55(13):1300-12
pubmed: 17626262
J Neurosci. 2003 Feb 1;23(3):766-76
pubmed: 12574405
PLoS One. 2012;7(10):e46715
pubmed: 23056417
Glia. 2018 Feb;66(2):428-444
pubmed: 29105869
Hum Mol Genet. 2005 Oct 1;14(19):2787-99
pubmed: 16103128
Am J Hum Genet. 2000 Feb;66(2):733-9
pubmed: 10677334
J Immunol. 2006 Jul 15;177(2):1272-81
pubmed: 16818787
Neuromolecular Med. 2019 Sep;21(3):303-313
pubmed: 31134486
Hum Mol Genet. 2011 Aug 15;20(16):3266-77
pubmed: 21624973
Neuroscientist. 2019 Jun;25(3):227-240
pubmed: 29931997
Glia. 2019 Oct;67(10):1821-1841
pubmed: 31033014
J Neurosci. 2009 Jun 17;29(24):7743-52
pubmed: 19535586
J Cell Sci. 2020 Feb 20;133(4):
pubmed: 31964703
Mol Cell Biol. 2003 Aug;23(16):5790-802
pubmed: 12897149
Lancet Neurol. 2013 Jul;12(7):659-68
pubmed: 23707145
Development. 1993 May;118(1):283-95
pubmed: 8375338
J Neurosci. 2013 May 1;33(18):7985-96
pubmed: 23637189
Brain. 2013 Jan;136(Pt 1):209-22
pubmed: 23365098
Immunology. 2014 Mar;141(3):302-13
pubmed: 23981039
Glia. 2011 Jul;59(7):1064-74
pubmed: 21538560
Exp Mol Med. 2018 Mar 16;50(3):e457
pubmed: 29546879
Annu Rev Biochem. 2005;74:739-89
pubmed: 15952902
Acta Neuropathol. 2015 Oct;130(4):469-86
pubmed: 26296699
Front Neurosci. 2014 May 09;8:103
pubmed: 24847203
J Exp Med. 2002 Jan 7;195(1):99-111
pubmed: 11781369
J Mol Neurosci. 2008 May;35(1):101-16
pubmed: 18236012
Brain. 1949 Sep;72(3):373-81, 3 pl
pubmed: 15409268
J Neuropathol Exp Neurol. 2004 Jun;63(6):618-30
pubmed: 15217090
Ann Neurol. 2015 Jan;77(1):114-31
pubmed: 25382142
World J Pediatr. 2019 Oct;15(5):454-464
pubmed: 31372844
J Cereb Blood Flow Metab. 2010 Mar;30(3):459-73
pubmed: 19904283
J Neuropathol Exp Neurol. 2005 May;64(5):412-9
pubmed: 15892299
Mitochondrion. 2010 Mar;10(2):143-50
pubmed: 20005986
Mol Neurodegener. 2017 May 25;12(1):42
pubmed: 28545479
Hum Genet. 2002 Mar;110(3):279-83
pubmed: 11935341
J Neuropathol Exp Neurol. 2005 Sep;64(9):770-5
pubmed: 16141786
Neural Regen Res. 2017 Oct;12(10):1610-1612
pubmed: 29171421
Nat Commun. 2015 Nov 26;6:8966
pubmed: 26608817
Pharmacol Ther. 2019 Feb;194:44-58
pubmed: 30189290
Hum Mol Genet. 2005 Aug 15;14(16):2443-58
pubmed: 16014634
Front Mol Neurosci. 2014 Aug 08;7:73
pubmed: 25152710
Ann Clin Transl Neurol. 2015 Jul;2(7):774-9
pubmed: 26273690
Annu Rev Immunol. 2014;32:367-402
pubmed: 24471431
Eur J Paediatr Neurol. 2002;6 Suppl A:A27-31; discussion A37-9, A77-86
pubmed: 12365358
Nat Commun. 2015 Oct 06;6:8518
pubmed: 26439639
Brain Pathol. 2018 Nov;28(6):806-821
pubmed: 30062819
Biochem J. 2006 Mar 15;394(Pt 3):527-43
pubmed: 16492141
Cells. 2020 Mar 03;9(3):
pubmed: 32138223
J Neurol. 2002 May;249(5):584-95
pubmed: 12021949
Brain Res Brain Res Rev. 2000 Apr;32(1):29-44
pubmed: 10751655
J Neurosci. 2012 Apr 11;32(15):5017-23
pubmed: 22496548
Front Cell Neurosci. 2015 Apr 01;9:66
pubmed: 25883547
J Immunol. 2001 Jun 15;166(12):7617-24
pubmed: 11390519
J Biol Chem. 2010 Apr 2;285(14):10527-37
pubmed: 20110364
J Neurochem. 2017 Jun;141(5):694-707
pubmed: 28306143
J Lipid Res. 2004 Aug;45(8):1375-97
pubmed: 15254070
Hum Genet. 2002 Aug;111(2):214-8
pubmed: 12189496
Nat Commun. 2014 Mar 19;5:3475
pubmed: 24647135
J Neurosci. 2001 Sep 15;21(18):7046-52
pubmed: 11549714
J Clin Invest. 2016 Apr 1;126(4):1512-24
pubmed: 26974157
Int J Mol Sci. 2019 Aug 09;20(16):
pubmed: 31405033
Neuroscience. 2010 Mar 17;166(2):464-75
pubmed: 20035837
Brain Pathol. 2018 May;28(3):399-407
pubmed: 29740948
Acta Neurol Belg. 2020 Oct;120(5):1177-1179
pubmed: 31240666
Am J Hum Genet. 2001 Apr;68(4):831-8
pubmed: 11254442
J Neurosci. 2007 Feb 21;27(8):2013-24
pubmed: 17314297
Acta Neuropathol. 2017 Sep;134(3):351-382
pubmed: 28638987
J Neuropathol Exp Neurol. 2006 Jul;65(7):707-15
pubmed: 16825957
Nature. 2016 Apr 14;532(7598):195-200
pubmed: 27027288
Science. 1993 Jan 29;259(5095):689-92
pubmed: 8430320
Front Pharmacol. 2013 Sep 26;4:120
pubmed: 24133447
Acta Neuropathol. 1999 Aug;98(2):212-6
pubmed: 10442562
J Neurosci. 2013 Apr 24;33(17):7439-50
pubmed: 23616550
Mol Cell Biol. 2002 Feb;22(3):816-34
pubmed: 11784858
J Virol. 2005 Sep;79(17):11457-66
pubmed: 16103196
J Neuroimmunol. 2005 Jan;158(1-2):58-66
pubmed: 15589038
J Cell Physiol. 1994 Apr;159(1):41-50
pubmed: 8138590
Cell Stem Cell. 2018 Aug 02;23(2):239-251.e6
pubmed: 30075130
Mol Neurobiol. 2010 Jun;41(2-3):232-41
pubmed: 20148316
Cells. 2020 Feb 07;9(2):
pubmed: 32046185
Metab Brain Dis. 2016 Oct;31(5):1171-9
pubmed: 27389245
Life Sci. 2011 Aug 1;89(5-6):141-6
pubmed: 21684291
J Neuropathol Exp Neurol. 2010 Apr;69(4):335-45
pubmed: 20448479
Acta Neuropathol. 1996 Aug;92(2):206-12
pubmed: 8841668
J Neuropathol Exp Neurol. 2011 Jan;70(1):69-82
pubmed: 21157376
Brain. 2013 Jan;136(Pt 1):245-58
pubmed: 23365100
J Cell Sci. 2006 Feb 1;119(Pt 3):532-41
pubmed: 16418219
Neurochem Res. 1999 Feb;24(2):331-8
pubmed: 9972883
Acta Neuropathol. 2006 Aug;112(2):195-204
pubmed: 16733654
Glia. 2015 Jun;63(6):1021-35
pubmed: 25739948
Front Cell Dev Biol. 2016 Jun 28;4:71
pubmed: 27551677
J Biol Chem. 2006 Dec 15;281(50):38634-43
pubmed: 17038307
Brain Res. 2007 Jul 23;1159:8-17
pubmed: 17572395
CNS Neurosci Ther. 2019 Jun;25(6):759-771
pubmed: 30720246
PLoS One. 2016 Jun 20;11(6):e0157258
pubmed: 27322623
Exp Neurol. 2014 Aug;258:5-16
pubmed: 25017883
Brain Sci. 2018 Mar 22;8(4):
pubmed: 29565275
J Neurosci. 2015 Mar 11;35(10):4427-39
pubmed: 25762685
Brain Behav Immun. 2016 Aug;56:1-9
pubmed: 26674996
Front Neurosci. 2014 Oct 07;8:315
pubmed: 25339862
Hum Mol Genet. 2013 Nov 1;22(21):4405-16
pubmed: 23793458
J Neurochem. 2012 Jul;122(2):344-55
pubmed: 22587438
Glia. 2008 Apr;56(5):568-78
pubmed: 18240301
J Neurochem. 2013 Oct;127(2):259-70
pubmed: 23647102
Glia. 2018 Oct;66(10):2058-2078
pubmed: 30051922
Curr Mol Med. 2006 Feb;6(1):87-97
pubmed: 16472116
J Proteome Res. 2016 Jul 1;15(7):2265-82
pubmed: 27193225
Mol Biol Cell. 2008 Oct;19(10):4521-33
pubmed: 18685083
Am J Hum Genet. 2003 Feb;72(2):408-18
pubmed: 12457340
Front Cell Neurosci. 2018 Oct 02;12:329
pubmed: 30333729
Acta Neuropathol Commun. 2017 Mar 31;5(1):27
pubmed: 28359321
Nat Genet. 2001 Jan;27(1):117-20
pubmed: 11138011
J Neurosci. 2011 Jan 12;31(2):538-48
pubmed: 21228163
Nat Med. 2005 Mar;11(3):277-83
pubmed: 15723074