Single Nucleotide Polymorphisms Associated With Gut Homeostasis Influence Risk and Age-at-Onset of Parkinson's Disease.

Parkinson's disease gene-environment interactions gut inflammation gut-brain axis peptidoglycan recognition protein single nucleotide polymorphisms toll-like receptors

Journal

Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824

Informations de publication

Date de publication:
2020
Historique:
received: 08 09 2020
accepted: 20 10 2020
entrez: 17 12 2020
pubmed: 18 12 2020
medline: 18 12 2020
Statut: epublish

Résumé

Research is increasingly focusing on gut inflammation as a contributor to Parkinson's disease (PD). Such gut inflammation is proposed to arise from a complex interaction between various genetic, environmental, and lifestyle factors, however these factors are under-characterized. This study investigated the association between PD and single-nucleotide polymorphisms (SNPs) in genes responsible for binding of bacterial metabolites and intestinal homeostasis, which have been implicated in intestinal infections or inflammatory bowel disease. A case-control analysis was performed utilizing the following cohorts: (i) patients from the Australian Parkinson's Disease Registry (APDR) (

Identifiants

pubmed: 33328979
doi: 10.3389/fnagi.2020.603849
pmc: PMC7718032
doi:

Types de publication

Journal Article

Langues

eng

Pagination

603849

Informations de copyright

Copyright © 2020 Gorecki, Bakeberg, Theunissen, Kenna, Hoes, Pfaff, Akkari, Dunlop, Kõks, Mastaglia and Anderton.

Références

Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S41-6
pubmed: 26459660
J Neurogastroenterol Motil. 2019 Jul 1;25(3):363-376
pubmed: 31327219
Expert Opin Ther Targets. 2020 Jul;24(7):601-604
pubmed: 32349553
Neurosci Lett. 2017 Aug 24;656:72-76
pubmed: 28729076
Mov Disord. 2012 May;27(6):771-4
pubmed: 22314772
Neuropathol Appl Neurobiol. 2007 Dec;33(6):599-614
pubmed: 17961138
Parkinsons Dis. 2019 May 29;2019:3124295
pubmed: 31275543
Dig Dis Sci. 2016 Oct;61(10):2908-2920
pubmed: 27384052
J Neuroinflammation. 2018 Jun 4;15(1):172
pubmed: 29866153
J Immunol. 2007 May 15;178(10):6387-94
pubmed: 17475868
Gut. 2019 Jan;68(1):18-24
pubmed: 29785965
World J Gastrointest Oncol. 2020 May 15;12(5):535-548
pubmed: 32461785
Parkinsonism Relat Disord. 2016 Nov;32:66-72
pubmed: 27591074
Eur J Neurol. 2012 Jun;19(6):864-9
pubmed: 22248366
Infect Immun. 2018 Aug 22;86(9):
pubmed: 29914927
Parkinsonism Relat Disord. 2014 Jan;20(1):82-7
pubmed: 24120951
Nat Rev Gastroenterol Hepatol. 2020 May;17(5):263-278
pubmed: 32103203
Ann Neurol. 2006 Feb;59(2):298-309
pubmed: 16358335
Mov Disord. 2020 Mar;35(3):431-442
pubmed: 31737957
J Parkinsons Dis. 2019;9(s2):S313-S322
pubmed: 31594249
Neurosci Lett. 2006 Mar 20;396(1):67-72
pubmed: 16330147
Infection. 2013 Oct;41(5):941-8
pubmed: 23526294
Lancet Neurol. 2019 Dec;18(12):1091-1102
pubmed: 31701892
Parkinsonism Relat Disord. 2018 May;50:104-107
pubmed: 29454662
Neuron. 2019 Aug 21;103(4):627-641.e7
pubmed: 31255487
Curr Aging Sci. 2014;7(2):101-9
pubmed: 25101650
Occup Environ Med. 2007 Oct;64(10):673-80
pubmed: 17449559
Neurobiol Dis. 2013 Feb;50:42-8
pubmed: 23017648
Parkinsonism Relat Disord. 2019 Oct;67:105-112
pubmed: 31494049
Trends Neurosci. 2019 Jan;42(1):4-13
pubmed: 30342839
J Immunol. 2007 Jan 15;178(2):970-5
pubmed: 17202359
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4659-65
pubmed: 20615996
Mov Disord. 2019 Jun;34(6):801-811
pubmed: 31091353
J Neurol Neurosurg Psychiatry. 2016 Jul;87(7):710-6
pubmed: 26345189
Genome Med. 2017 Apr 28;9(1):39
pubmed: 28449715
PLoS One. 2014 Jun 27;9(6):e98815
pubmed: 24971461
Mov Disord. 2017 May;32(5):739-749
pubmed: 28195358
Front Neurosci. 2019 Sep 27;13:992
pubmed: 31611762
Asian Pac J Cancer Prev. 2016;17(7):3391-4
pubmed: 27509981
Acta Neurol Scand. 2017 Mar;135(3):273-284
pubmed: 27273099
Neurobiol Dis. 2020 Apr;137:104782
pubmed: 31991247
J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4
pubmed: 1564476
Mem Inst Oswaldo Cruz. 2017 Apr;112(4):260-268
pubmed: 28327786
Neurology. 2015 Feb 10;84(6):609-16
pubmed: 25589666
Clin Exp Allergy. 2014 Oct;44(10):1255-65
pubmed: 25146491
Gut. 2019 May;68(5):829-843
pubmed: 30554160
Bioinformatics. 2011 Aug 1;27(15):2156-8
pubmed: 21653522
Turk J Gastroenterol. 2018 May;29(3):283-291
pubmed: 29755012
Gastroenterology. 2006 Jul;131(1):117-29
pubmed: 16831596
Expert Opin Drug Metab Toxicol. 2016;12(2):135-47
pubmed: 26727306
Clin Nutr. 2019 Jun;38(3):1031-1035
pubmed: 29891223
Am J Pathol. 2013 Feb;182(2):375-87
pubmed: 23201091
Acta Neuropathol Commun. 2015 Mar 10;3:12
pubmed: 25775153
JAMA Netw Open. 2018 Sep 7;1(5):e182421
pubmed: 30646166
Int J Mol Sci. 2018 Sep 18;19(9):
pubmed: 30231491
Ann Neurol. 2015 Oct;78(4):522-9
pubmed: 26031848
mSystems. 2020 Sep 15;5(5):
pubmed: 32934117
J Mol Med (Berl). 2006 Dec;84(12):1055-66
pubmed: 17058067
PLoS One. 2013 Jun 19;8(6):e67393
pubmed: 23840689
Neurology. 2016 Sep 20;87(12):1274-80
pubmed: 27543643
Cell Microbiol. 2021 Jan;23(1):e13264
pubmed: 32945079
Ann Neurol. 2016 Jun;79(6):940-9
pubmed: 27015771
Innate Immun. 2010 Jun;16(3):168-74
pubmed: 20418257
J Neurochem. 2016 Dec;139(5):839-847
pubmed: 27637918
Front Neurosci. 2019 Aug 07;13:839
pubmed: 31440136
Sci Rep. 2018 Nov 8;8(1):16525
pubmed: 30410011
Parkinsonism Relat Disord. 2016 Nov;32:25-30
pubmed: 27545685
J Innate Immun. 2017;9(5):456-463
pubmed: 28651250
Nat Neurosci. 2020 Mar;23(3):327-336
pubmed: 32066981
PLoS Genet. 2011 Aug;7(8):e1002237
pubmed: 21876681
Mov Disord. 2013 Feb;28(2):237-40
pubmed: 23362176
Int J Biol Macromol. 2020 Dec 1;164:884-891
pubmed: 32707285
Gut Pathog. 2019 Jun 15;11:31
pubmed: 31249629
Nature. 2019 Jul;571(7766):565-569
pubmed: 31316206
PLoS One. 2011;6(12):e28032
pubmed: 22145021
Acta Neuropathol. 2019 Feb;137(2):359-361
pubmed: 30506319
Mov Disord. 2014 Aug;29(9):1171-80
pubmed: 24838182
Gut. 2020 Jun;69(6):1154-1156
pubmed: 31201287
PLoS One. 2018 May 22;13(5):e0195392
pubmed: 29787561
Environ Res. 2016 Nov;151:713-720
pubmed: 27640071
NPJ Parkinsons Dis. 2017 Jan 11;3:3
pubmed: 28649603
Front Neurosci. 2020 Jan 31;14:47
pubmed: 32082115
Helicobacter. 2013 Feb;18(1):13-21
pubmed: 23067142
J Neurol Sci. 2017 Apr 15;375:355-359
pubmed: 28320167
Neurobiol Aging. 2012 Oct;33(10):2528.e1-6
pubmed: 22763023

Auteurs

Anastazja M Gorecki (AM)

Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.
School of Biological Sciences, University of Western Australia, Crawley, WA, Australia.

Megan C Bakeberg (MC)

Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.
Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, WA, Australia.

Frances Theunissen (F)

Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.
The Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, WA, Australia.

Jade E Kenna (JE)

Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.
Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, WA, Australia.

Madison E Hoes (ME)

Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.

Abigail L Pfaff (AL)

Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.
The Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, WA, Australia.

P Anthony Akkari (PA)

Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.
Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, WA, Australia.
The Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, WA, Australia.

Sarah A Dunlop (SA)

School of Biological Sciences, University of Western Australia, Crawley, WA, Australia.
Minderoo Foundation, Perth, WA, Australia.

Sulev Kõks (S)

Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.
The Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, WA, Australia.

Frank L Mastaglia (FL)

Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.
Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, WA, Australia.

Ryan S Anderton (RS)

Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.
Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, WA, Australia.
Institute for Health Research, University of Notre Dame Australia, Fremantle, WA, Australia.
School of Health Sciences, University of Notre Dame Australia, Fremantle, WA, Australia.

Classifications MeSH