Exosomal MiR-769-5p Exacerbates Ultraviolet-Induced Bystander Effect by Targeting
TGFBR1
exosomes
miRNA
photo damage
ultraviolet–radiation induced bystander effects
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
09
2020
accepted:
28
10
2020
entrez:
17
12
2020
pubmed:
18
12
2020
medline:
18
12
2020
Statut:
epublish
Résumé
Exosomal microRNAs have been investigated in bystander effect, but it is unclear whether microRNA works in ultraviolet radiation-induced bystander effects (UV-RIBEs) and what the underlying mechanism could be. Exosomes from ultraviolet (UV)-irradiated human skin fibroblasts (HSFs) were isolated and transferred to normal HSFs, followed by the detection of proliferation rate, oxidative damage level, and apoptosis rate. Exosomal miRNAs were evaluated and screened with miRNA sequencing and quantitative reverse transcriptase-polymerase chain reaction method. MiRNA shuttle and bystander photodamage reactions were observed after transfection of miR-769-5p. MiR-769-5p targeting gene transforming growth factor-β1 (
Identifiants
pubmed: 33329055
doi: 10.3389/fphys.2020.603081
pmc: PMC7719707
doi:
Types de publication
Journal Article
Langues
eng
Pagination
603081Informations de copyright
Copyright © 2020 Ni, Ma, Tao, Liu, Hua, Cheng, Wang, Zhou and Luo.
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