Glutamate Systems in DSM-5 Anxiety Disorders: Their Role and a Review of Glutamate and GABA Psychopharmacology.
anxiety
clinical trials
glutamate
pharmacology
preclinical trials
psychiatry
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
04
2020
accepted:
12
10
2020
entrez:
17
12
2020
pubmed:
18
12
2020
medline:
18
12
2020
Statut:
epublish
Résumé
Serotonin reuptake inhibitors and benzodiazepines are evidence-based pharmacological treatments for Anxiety Disorders targeting serotonin and GABAergic systems, respectively. Although clearly effective, these medications fail to improve anxiety symptoms in a significant proportion of patients. New insights into the glutamate system have directed attention toward drugs that modulate glutamate as potential alternative treatments for anxiety disorders. Here we summarize the current understanding of the potential role of glutamate neurotransmission in anxiety disorders and highlight specific glutamate receptors that are potential targets for novel anxiety disorder treatments. We also review clinical trials of medications targeting the glutamate system in DSM-5 anxiety disorders. Understanding the role of the glutamate system in the pathophysiology of anxiety disorder may aid in developing novel pharmacological agents that are effective in treating anxiety disorders.
Identifiants
pubmed: 33329087
doi: 10.3389/fpsyt.2020.548505
pmc: PMC7710541
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
548505Informations de copyright
Copyright © 2020 Nasir, Trujillo, Levine, Dwyer, Rupp and Bloch.
Références
Neurosci Biobehav Rev. 2015 Aug;55:294-321
pubmed: 25957927
J Psychopharmacol. 2018 Jun;32(6):663-667
pubmed: 29561204
J Pharmacol Exp Ther. 1998 Feb;284(2):651-60
pubmed: 9454811
Neuropsychopharmacology. 2004 Mar;29(3):502-13
pubmed: 14694349
Int Clin Psychopharmacol. 2017 Jan;32(1):49-55
pubmed: 27643884
Nat Rev Drug Discov. 2008 May;7(5):426-37
pubmed: 18425072
J Clin Psychiatry. 2014 Jun;75(6):628-36
pubmed: 25004186
Nat Rev Neurosci. 2010 Oct;11(10):682-96
pubmed: 20842175
Drugs. 1997 Nov;54(5):752-73
pubmed: 9360061
Expert Opin Pharmacother. 2001 Jan;2(1):179-87
pubmed: 11336578
Psychopharmacology (Berl). 2004 Mar;172(2):225-9
pubmed: 14586539
Arch Gen Psychiatry. 2006 Jul;63(7):769-76
pubmed: 16818866
Neurochem Int. 2009 Jul-Aug;55(1-3):85-97
pubmed: 19428811
J Psychiatry Neurosci. 2000 May;25(3):255-61
pubmed: 10863885
Depress Anxiety. 2004;19(2):112-20
pubmed: 15022146
J Clin Psychiatry. 2005 Nov;66(11):1401-8
pubmed: 16420077
Curr Drug Targets. 2013 Mar;14(3):353-64
pubmed: 23256724
Arch Gen Psychiatry. 2009 Jul;66(7):756-63
pubmed: 19581567
Neuropsychopharmacology. 2009 Nov;34(12):2489-96
pubmed: 19675532
J Clin Psychiatry. 2005;66 Suppl 2:4-8
pubmed: 15762813
Prog Neuropsychopharmacol Biol Psychiatry. 2015 Apr 3;58:97-104
pubmed: 25549832
Psychopharmacology (Berl). 2005 Apr;179(1):4-29
pubmed: 15731895
J Clin Psychiatry. 2006 May;67(5):771-82
pubmed: 16841627
Ann Clin Psychiatry. 2016 Aug;28(3):190-6
pubmed: 27490835
Magn Reson Med. 1998 Jul;40(1):66-71
pubmed: 9660555
Expert Opin Emerg Drugs. 2015 Sep;20(3):393-406
pubmed: 26012843
Am J Psychiatry. 2000 Jul;157(7):1175-7
pubmed: 10873933
Pharmacol Biochem Behav. 2012 Feb;100(4):775-800
pubmed: 21708184
CNS Drugs. 2010 Aug;24(8):669-93
pubmed: 20658799
Behav Neurosci. 2002 Dec;116(6):1075-83
pubmed: 12492306
Clin Psychol Rev. 2015 Dec;42:72-82
pubmed: 26319194
Transl Psychiatry. 2012 Nov 13;2:e184
pubmed: 23149448
J Clin Psychiatry. 2017 Jul;78(7):e766-e773
pubmed: 28617566
Breast Cancer Res Treat. 2012 Nov;136(2):479-86
pubmed: 23053645
Am J Psychiatry. 2003 Mar;160(3):533-40
pubmed: 12611835
Arch Gen Psychiatry. 2009 Nov;66(11):1233-41
pubmed: 19884611
Neuropsychopharmacology. 2017 Jan;42(1):193-215
pubmed: 27629368
Behav Neurosci. 2004 Jun;118(3):505-13
pubmed: 15174928
Hum Brain Mapp. 2000 Dec;11(4):261-72
pubmed: 11144755
J Psychopharmacol. 2005 Sep;19(5):551-3
pubmed: 16166192
Neuropsychopharmacology. 2011 Jan;36(1):274-93
pubmed: 20631689
PLoS One. 2019 Oct 17;14(10):e0223729
pubmed: 31622374
Am J Psychiatry. 2004 Jun;161(6):1119-21
pubmed: 15169704
J Clin Child Adolesc Psychol. 2018 Mar-Apr;47(2):266-281
pubmed: 28956620
Psychol Med. 2016 May;46(7):1459-72
pubmed: 26867988
J Psychopharmacol. 2017 Oct;31(10):1302-1305
pubmed: 28441895
Pharmacol Rev. 1999 Mar;51(1):7-61
pubmed: 10049997
Neurobiol Learn Mem. 2005 May;83(3):224-31
pubmed: 15820858
Eur Psychiatry. 2008 Mar;23(2):109-14
pubmed: 17945470
Nat Rev Drug Discov. 2005 Feb;4(2):131-44
pubmed: 15665858
Pharmacopsychiatry. 2009 Nov;42(6):266-9
pubmed: 19924586
Arch Gen Psychiatry. 2005 Sep;62(9):1022-30
pubmed: 16143734
CNS Spectr. 2020 Jun;25(3):331-342
pubmed: 31339086
Int Clin Psychopharmacol. 2015 Jul;30(4):183-92
pubmed: 25932596
Behav Neurol. 2018 Nov 15;2018:2064027
pubmed: 30581496
Clin Pharmacol Drug Dev. 2018 Mar;7(3):228-232
pubmed: 29579375
Arch Gen Psychiatry. 2005 Jun;62(6):617-27
pubmed: 15939839
Psychiatry Res. 2001 Aug 5;103(1):1-14
pubmed: 11472786
Braz J Psychiatry. 2013;35 Suppl 2:S101-11
pubmed: 24271222
Ann Clin Psychiatry. 2012 Feb;24(1):6-22
pubmed: 22303519
Am J Psychiatry. 1998 Sep;155(9):1189-95
pubmed: 9734541
Curr Pharm Des. 2015;21(34):4943-59
pubmed: 26365137
Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):675-679
pubmed: 19569082
Biol Psychiatry. 2008 Mar 15;63(6):544-9
pubmed: 18179785
Can J Psychiatry. 1990 Apr;35(3):248-50
pubmed: 2111204
Br J Psychiatry. 1998 Jul;173:54-60
pubmed: 9850204
J Clin Psychiatry. 2004 Sep;65(9):1219-22
pubmed: 15367048
J Clin Psychiatry. 2010 May;71(5):627-31
pubmed: 20021997
J Child Adolesc Psychopharmacol. 2012 Dec;22(6):472-3
pubmed: 23234593
Prog Neurobiol. 2007 Feb;81(2):89-131
pubmed: 17275978
J Neurosci. 2001 Nov 15;21(22):RC181
pubmed: 11698619
Mediators Inflamm. 2008;2008:716458
pubmed: 18483565
Neuropharmacology. 2019 Sep 1;155:173-184
pubmed: 31153808
Eur Neuropsychopharmacol. 2004 May;14(3):175-83
pubmed: 15056476
JAMA Psychiatry. 2017 May 1;74(5):501-510
pubmed: 28122091
Psychopharmacology (Berl). 2005 Jun;180(1):159-68
pubmed: 15682295
NMR Biomed. 2013 Dec;26(12):1630-46
pubmed: 24123328
Neuropsychiatr Dis Treat. 2009;5:237-47
pubmed: 19557118
Neuropsychopharmacology. 2005 Sep;30(9):1735-40
pubmed: 15841109
Psychopharmacology (Berl). 2005 Apr;179(1):218-29
pubmed: 15739074
Expert Opin Drug Saf. 2014 Oct;13(10):1361-74
pubmed: 25148932
Int J Chron Obstruct Pulmon Dis. 2006;1(2):99-106
pubmed: 18046886
Neuropharmacology. 2000 Apr 27;39(7):1139-46
pubmed: 10760357
J Pharm Sci. 1973 Aug;62(8):1344-6
pubmed: 4725183
Pharmacol Rev. 2018 Jul;70(3):621-660
pubmed: 29945898
Pharmacol Rev. 2010 Sep;62(3):405-96
pubmed: 20716669
J Clin Psychiatry. 1993 Dec;54 Suppl:19-25
pubmed: 8276746
Neuron. 2005 Feb 17;45(4):539-52
pubmed: 15721240
Transl Psychiatry. 2019 Nov 7;9(1):280
pubmed: 31699965
J Psychopharmacol. 2015 Oct;29(10):1047-60
pubmed: 26259772
Neurosci Lett. 2017 May 10;649:147-155
pubmed: 27916636
Biol Psychiatry. 2002 May 15;51(10):775-87
pubmed: 12007451
Br J Psychiatry. 2001 Dec;179:514-8
pubmed: 11731354
Arch Gen Psychiatry. 2009 Apr;66(4):408-16
pubmed: 19349310
Am J Psychiatry. 1998 Nov;155(11):1584-91
pubmed: 9812122
Mayo Clin Proc. 2016 Sep;91(9):1280-6
pubmed: 27594188
Psychiatry Res. 2019 Aug;278:294-302
pubmed: 31254879
Hum Psychopharmacol. 2007 Jun;22(4):241-4
pubmed: 17476705
J Clin Psychopharmacol. 2000 Aug;20(4):467-71
pubmed: 10917408
Clin Psychopharmacol Neurosci. 2015 Apr 30;13(1):12-24
pubmed: 25912534
J Clin Psychiatry. 2016 Apr;77(4):e457-66
pubmed: 27137430
Am J Psychiatry. 2005 Dec;162(12):2379-81
pubmed: 16330605
Behav Neurosci. 1992 Jun;106(3):569-574
pubmed: 1352104
Neuropharmacology. 2012 Jan;62(1):42-53
pubmed: 21889518
Pharmacogenet Genomics. 2013 Apr;23(4):236-41
pubmed: 23407051
Cell. 1996 Dec 27;87(7):1327-38
pubmed: 8980238
Depress Anxiety. 2019 Mar;36(3):198-212
pubmed: 30479005
PLoS One. 2017 Mar 10;12(3):e0173660
pubmed: 28282427
Int Clin Psychopharmacol. 2012 May;27(3):142-50
pubmed: 22302014
J Clin Psychiatry. 2015 Aug;76(8):1050-9
pubmed: 26335083
Ann Clin Psychiatry. 2005 Jul-Sep;17(3):167-72
pubmed: 16433059
Psychiatry Res. 2005 Nov 15;137(1-2):61-70
pubmed: 16226812
Neuropsychopharmacology. 2018 Jan;43(2):325-333
pubmed: 28849779
J Clin Psychiatry. 2015 Aug;76(8):1075-84
pubmed: 26214725
Depress Anxiety. 2009;26(12):1165-71
pubmed: 19842165
Am J Med Genet B Neuropsychiatr Genet. 2009 Sep 5;150B(6):886-92
pubmed: 19152386
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Jun;27(4):687-700
pubmed: 12787858
Nat Rev Neurosci. 2011 Nov 30;13(1):22-37
pubmed: 22127301
Behav Neurosci. 2003 Apr;117(2):341-9
pubmed: 12708530
Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 5;144B(8):1027-33
pubmed: 17894418
Pharmacol Ther. 2007 Jul;115(1):116-47
pubmed: 17582504
Psychiatr Serv. 2015 Sep;66(9):938-45
pubmed: 25975886
Biol Psychiatry. 2003 Nov 15;54(10):1105-17
pubmed: 14625154
Biol Psychiatry. 2000 Feb 15;47(4):351-4
pubmed: 10686270
Arch Gen Psychiatry. 2006 Jul;63(7):778-85
pubmed: 16818867
J Clin Psychiatry. 2004 Dec;65(12):1674-8
pubmed: 15641873
Psychopharmacol Bull. 2007;40(3):32-40
pubmed: 18007567
Int Clin Psychopharmacol. 2003 May;18(3):169-72
pubmed: 12702897
Curr Drug Targets CNS Neurol Disord. 2002 Apr;1(2):191-213
pubmed: 12769627
Psychiatry Res. 2011 Apr 30;192(1):45-54
pubmed: 21377338
J Clin Psychiatry. 2003;64 Suppl 3:21-7
pubmed: 12662130
J Clin Psychopharmacol. 1999 Aug;19(4):341-8
pubmed: 10440462
Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5160-5169
pubmed: 30796190
Brain Res. 2000 Oct 13;880(1-2):1-10
pubmed: 11032984
Pharmacol Rev. 1998 Dec;50(4):597-664
pubmed: 9860805
Arch Gen Psychiatry. 2006 Mar;63(3):298-304
pubmed: 16520435
J Clin Psychopharmacol. 2003 Jun;23(3):240-9
pubmed: 12826986
Neuroreport. 2005 Feb 8;16(2):183-6
pubmed: 15671874
Drugs Context. 2019 Apr 08;8:212305
pubmed: 31007698
Psychopharmacol Bull. 2009;42(1):81-93
pubmed: 19204653
JAMA Psychiatry. 2014 Jun;71(6):681-8
pubmed: 24740528
Curr Psychiatry Rep. 2007 Aug;9(4):278-83
pubmed: 17880858
PM R. 2010 Jan;2(1):37-42
pubmed: 20129511
Neuropharmacology. 2001 Jul;41(1):1-7
pubmed: 11445180
Psychiatry Clin Neurosci. 2015 Dec;69(12):782-90
pubmed: 26171979
J Am Acad Child Adolesc Psychiatry. 1993 Sep;32(5):1089-98
pubmed: 8175638
Psychiatry Res. 2019 Dec;282:112602
pubmed: 31630042
Depress Anxiety. 2010 Sep;27(9):791-8
pubmed: 20217852
J Pharmacol Exp Ther. 1998 May;285(2):527-32
pubmed: 9580593
J Neurosci. 2002 Mar 15;22(6):2343-51
pubmed: 11896173
Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):1000-2
pubmed: 18286588
Eur J Pharmacol. 2010 Jan 10;626(1):49-56
pubmed: 19836379
Am J Psychiatry. 1998 Jan;155(1):36-42
pubmed: 9433336
Cerebellum. 2007;6(4):308-14
pubmed: 17853088
Endocrinology. 1970 Oct;87(4):738-43
pubmed: 5453288
Neurochem Res. 2019 Apr;44(4):829-838
pubmed: 30656595
J Am Acad Child Adolesc Psychiatry. 2000 Sep;39(9):1096-103
pubmed: 10986805
Eur J Pharmacol. 1996 Dec 27;318(1):1-6
pubmed: 9007504
CNS Drugs. 2008;22(9):761-86
pubmed: 18698875
Neuropsychopharmacology. 2013 Nov;38(12):2475-83
pubmed: 23783065
Am J Drug Alcohol Abuse. 2008;34(6):683-91
pubmed: 18850500
Am J Addict. 2017 Oct;26(7):660-666
pubmed: 28898494
Expert Opin Drug Saf. 2018 Mar;17(3):315-324
pubmed: 29357714
Neuropsychopharmacology. 2016 Jan;41(1):297-319
pubmed: 26321314
J Neurochem. 1993 May;60(5):1650-7
pubmed: 8097232
Cell Mol Neurobiol. 2000 Jun;20(3):319-29
pubmed: 10789831
J Neurosci. 2017 Oct 4;37(40):9686-9704
pubmed: 28877967
Am J Med. 1991 Sep 30;91(3C):131S-139S
pubmed: 1928204
Psychiatry Res. 2006 Mar 31;146(2):137-47
pubmed: 16507346
Stroke. 2018 Jul;49(7):1727-1733
pubmed: 29866754
Pharmacol Biochem Behav. 2014 Jun;121:132-7
pubmed: 24239785