Conjugation of Synthetic Polyproline Moietes to Lipid II Binding Fragments of Nisin Yields Active and Stable Antimicrobials.

RiPPs click chemistry lantibiotics nisin polyproline peptides

Journal

Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977

Informations de publication

Date de publication:
2020
Historique:
received: 23 06 2020
accepted: 30 10 2020
entrez: 17 12 2020
pubmed: 18 12 2020
medline: 18 12 2020
Statut: epublish

Résumé

Coupling functional moieties to lantibiotics offers exciting opportunities to produce novel derivatives with desirable properties enabling new functions and applications. Here, five different synthetic hydrophobic polyproline peptides were conjugated to either nisin AB (the first two rings of nisin) or nisin ABC (the first three rings of nisin) by using click chemistry. The antimicrobial activity of nisin ABC + O6K3 against

Identifiants

pubmed: 33329435
doi: 10.3389/fmicb.2020.575334
pmc: PMC7715017
doi:

Types de publication

Journal Article

Langues

eng

Pagination

575334

Informations de copyright

Copyright © 2020 Deng, Viel, Kubyshkin, Budisa and Kuipers.

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Auteurs

Jingjing Deng (J)

Department of Molecular Genetics, University of Groningen, Groningen, Netherlands.

Jakob H Viel (JH)

Department of Molecular Genetics, University of Groningen, Groningen, Netherlands.

Vladimir Kubyshkin (V)

Institute of Chemistry, Technical University of Berlin, Berlin, Germany.
Department of Chemistry, University of Manitoba, Winnipeg, MB, Canada.

Nediljko Budisa (N)

Institute of Chemistry, Technical University of Berlin, Berlin, Germany.
Department of Chemistry, University of Manitoba, Winnipeg, MB, Canada.

Oscar P Kuipers (OP)

Department of Molecular Genetics, University of Groningen, Groningen, Netherlands.

Classifications MeSH