Involvement of Mesenchymal Stem Cells in Oral Mucosal Bacterial Immunotherapy.
Administration, Sublingual
Animals
Bacterial Vaccines
/ administration & dosage
Cytokines
/ metabolism
Host-Pathogen Interactions
/ immunology
Humans
Immunization
Immunologic Memory
Immunomodulation
Immunophenotyping
Inflammation
/ etiology
Leukocytes
/ immunology
Lymphocyte Activation
/ immunology
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
/ cytology
Mice
Mouth Mucosa
/ immunology
Receptors, Pattern Recognition
/ metabolism
immunomodulation
mesenchymal stem cells
pattern recognition receptors
polybacterial preparation
short-term memory
sublingual mucosal immunotherapy
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
05
2020
accepted:
19
10
2020
entrez:
17
12
2020
pubmed:
18
12
2020
medline:
13
5
2021
Statut:
epublish
Résumé
Recent clinical observations indicate that bacterial vaccines induce cross-protection against infections produced by different microorganisms. MV130, a polyvalent bacterial sublingual preparation designed to prevent recurrent respiratory infectious diseases, reduces the infection rate in patients with recurrent respiratory tract infections. On the other hand, mesenchymal stem cells (MSCs) are key cell components that contribute to the maintenance of tissue homeostasis and exert both immunostimulatory and immunosuppressive functions. Herein, we study the effects of MV130 in human MSC functionality as a potential mechanism that contributes to its clinical benefits. We provide evidence that during MV130 sublingual immunization of mice, resident oral mucosa MSCs can take up MV130 components and their numbers remain unchanged after vaccination, in contrast to granulocytes that are recruited from extramucosal tissues. MSCs treated
Identifiants
pubmed: 33329530
doi: 10.3389/fimmu.2020.567391
pmc: PMC7711618
doi:
Substances chimiques
Bacterial Vaccines
0
Cytokines
0
Receptors, Pattern Recognition
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
567391Informations de copyright
Copyright © 2020 Vázquez, Fernández-Sevilla, Jiménez, Pérez-Cabrera, Yañez, Subiza, Varas, Valencia and Vicente.
Déclaration de conflit d'intérêts
JS is the CEO of Inmunotek SL, a pharmaceutical company that manufactures bacterial vaccines. The authors declare that this study received funding from Inmunotek SL. The funder had the following involvement in the study: final writing and editing of the manuscript.
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