Macrophages in Organ Transplantation.
immune tolerance
macrophages
nanotherapy
organ transplantation
trained immunity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
07
2020
accepted:
20
10
2020
entrez:
17
12
2020
pubmed:
18
12
2020
medline:
23
6
2021
Statut:
epublish
Résumé
Current immunosuppressive therapy has led to excellent short-term survival rates in organ transplantation. However, long-term graft survival rates are suboptimal, and a vast number of allografts are gradually lost in the clinic. An increasing number of animal and clinical studies have demonstrated that monocytes and macrophages play a pivotal role in graft rejection, as these mononuclear phagocytic cells recognize alloantigens and trigger an inflammatory cascade that activate the adaptive immune response. Moreover, recent studies suggest that monocytes acquire a feature of memory recall response that is associated with a potent immune response. This form of memory is called "trained immunity," and it is retained by mechanisms of epigenetic and metabolic changes in innate immune cells after exposure to particular ligands, which have a direct impact in allograft rejection. In this review article, we highlight the role of monocytes and macrophages in organ transplantation and summarize therapeutic approaches to promote tolerance through manipulation of monocytes and macrophages. These strategies may open new therapeutic opportunities to increase long-term transplant survival rates in the clinic.
Identifiants
pubmed: 33329555
doi: 10.3389/fimmu.2020.582939
pmc: PMC7734247
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
582939Subventions
Organisme : NIAID NIH HHS
ID : R01 AI139623
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA078207
Pays : United States
Informations de copyright
Copyright © 2020 Ordikhani, Pothula, Sanchez-Tarjuelo, Jordan and Ochando.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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