Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report.

In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.

Informations de copyright

Copyright © 2020 Cenciarelli, Calbi, Barzaghi, Bernardo, Oltolini, Migliavacca, Gallo, Tucci, Fraschetta, Albertazzi, Fratini, Consiglieri, Giannelli, Dionisio, Sartirana, Racca, Camesasca, Peretto, Daverio, Esposito, De Cobelli, Silvani, Rabusin, Cara, Trabattoni, Dispinseri, Scarlatti, Piemonti, Lampasona, Cicalese, Aiuti and Ferrua.

Déclaration de conflit d'intérêts

The San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) is a joint venture between the Italian Telethon Foundation and Ospedale San Raffaele (OSR). WAS gene therapy was licensed to GlaxoSmithKline in 2014 and then transferred to Orchard Therapeutics (OTL) in April 2018. AA, FFe, MC and SC are investigators of trial # NCT03837483. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a past co-authorship with several of the authors VG, FB, MC, FFe, and AA.