Expert Consensus Guidelines on Minimally Invasive Donor Hepatectomy for Living Donor Liver Transplantation From Innovation to Implementation: A Joint Initiative From the International Laparoscopic Liver Society (ILLS) and the Asian-Pacific Hepato-Pancreato-Biliary Association (A-PHPBA).


Journal

Annals of surgery
ISSN: 1528-1140
Titre abrégé: Ann Surg
Pays: United States
ID NLM: 0372354

Informations de publication

Date de publication:
01 01 2021
Historique:
entrez: 17 12 2020
pubmed: 18 12 2020
medline: 12 2 2021
Statut: ppublish

Résumé

The Expert Consensus Guidelines initiative on MIDH for LDLT was organized with the goal of safe implementation and development of these complex techniques with donor safety as the main priority. Following the development of minimally invasive liver surgery, techniques of MIDH were developed with the aim of reducing the short- and long-term consequences of the procedure on liver donors. These techniques, although increasingly performed, lack clinical guidelines. A group of 12 international MIDH experts, 1 research coordinator, and 8 junior faculty was assembled. Comprehensive literature search was made and studies classified using the SIGN method. Based on literature review and experts opinions, tentative recommendations were made by experts subgroups and submitted to the whole experts group using on-line Delphi Rounds with the goal of obtaining >90% Consensus. Pre-conference meeting formulated final recommendations that were presented during the plenary conference held in Seoul on September 7, 2019 in front of a Validation Committee composed of LDLT experts not practicing MIDH and an international audience. Eighteen Clinical Questions were addressed resulting in 44 recommendations. All recommendations reached at least a 90% consensus among experts and were afterward endorsed by the validation committee. The Expert Consensus on MIDH has produced a set of clinical guidelines based on available evidence and clinical expertise. These guidelines are presented for a safe implementation and development of MIDH in LDLT Centers with the goal of optimizing donor safety, donor care, and recipient outcomes.

Sections du résumé

OBJECTIVE
The Expert Consensus Guidelines initiative on MIDH for LDLT was organized with the goal of safe implementation and development of these complex techniques with donor safety as the main priority.
BACKGROUND
Following the development of minimally invasive liver surgery, techniques of MIDH were developed with the aim of reducing the short- and long-term consequences of the procedure on liver donors. These techniques, although increasingly performed, lack clinical guidelines.
METHODS
A group of 12 international MIDH experts, 1 research coordinator, and 8 junior faculty was assembled. Comprehensive literature search was made and studies classified using the SIGN method. Based on literature review and experts opinions, tentative recommendations were made by experts subgroups and submitted to the whole experts group using on-line Delphi Rounds with the goal of obtaining >90% Consensus. Pre-conference meeting formulated final recommendations that were presented during the plenary conference held in Seoul on September 7, 2019 in front of a Validation Committee composed of LDLT experts not practicing MIDH and an international audience.
RESULTS
Eighteen Clinical Questions were addressed resulting in 44 recommendations. All recommendations reached at least a 90% consensus among experts and were afterward endorsed by the validation committee.
CONCLUSIONS
The Expert Consensus on MIDH has produced a set of clinical guidelines based on available evidence and clinical expertise. These guidelines are presented for a safe implementation and development of MIDH in LDLT Centers with the goal of optimizing donor safety, donor care, and recipient outcomes.

Identifiants

pubmed: 33332874
doi: 10.1097/SLA.0000000000004475
pii: 00000658-202101000-00016
doi:

Types de publication

Consensus Development Conference Journal Article Practice Guideline

Langues

eng

Sous-ensembles de citation

IM

Pagination

96-108

Informations de copyright

Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.

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Auteurs

Daniel Cherqui (D)

AP-HP, Hepatobiliary Center, Paul Brousse Hospital, Université Paris Saclay, Villejuif, France.

Ruben Ciria (R)

Unit of Hepatobiliary Surgery and Liver Transplantation. University Hospital Reina Sofía, Cordoba, Spain.

Choon Hyuck David Kwon (CHD)

Department of General Surgery, Digestive Disease & Surgery Institute, Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio.
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Ki-Hun Kim (KH)

Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Dieter Broering (D)

Organ Transplant Center, King Faisal Specialist Hospital and Research Center, Al Faisal University, Riyadh, KSA.

Go Wakabayashi (G)

Center for Advanced Treatment of Hepatobiliary and Pancreatic Diseases, Ageo Central General Hospital, Ageo, Japan.

Benjamin Samstein (B)

Department of Surgery, Division of Liver Transplantation and Hepatobiliary Surgery, Weill Cornell Medical College, New York, New York.

Roberto I Troisi (RI)

Organ Transplant Center, King Faisal Specialist Hospital and Research Center, Al Faisal University, Riyadh, KSA.
Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy; Department of Human Structure and Repair, Ghent University, Belgium.

Ho Seong Han (HS)

Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Fernando Rotellar (F)

Department of General Surgery, Clínica Universidad de Navarra, School of Medicine, University of Navarra, Pamplona, Spain.

Olivier Soubrane (O)

Department of Hepatopancreatobiliary Surgery and Liver Transplantation, Beaujon Hospital, Assistance Publique Hôpitaux de Paris and Université de Paris, Clichy, France.

Javier Briceño (J)

Unit of Hepatobiliary Surgery and Liver Transplantation. University Hospital Reina Sofía, Cordoba, Spain.

Felipe Alconchel (F)

Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain; Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain.

María Dolores Ayllón (MD)

Unit of Hepatobiliary Surgery and Liver Transplantation. University Hospital Reina Sofía, Cordoba, Spain.

Giammauro Berardi (G)

Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy; Department of Human Structure and Repair, Ghent University, Belgium.

Francois Cauchy (F)

Department of Hepatopancreatobiliary Surgery and Liver Transplantation, Beaujon Hospital, Assistance Publique Hôpitaux de Paris and Université de Paris, Clichy, France.

Irene Gómez Luque (IG)

Unit of Hepatobiliary Surgery and Liver Transplantation. University Hospital Reina Sofía, Cordoba, Spain.

Suk Kyun Hong (SK)

Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea.

Young-Yin Yoon (YY)

Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Hiroto Egawa (H)

Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University.

Jan Lerut (J)

Institut de Recherche Expérimentale et Clinique Université Catholique de Louvain Brussels, Belgium.

Chung-Mau Lo (CM)

Department of Surgery, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.

Mohamed Rela (M)

The Institute of Liver Disease and Transplantation, Dr. Rela Institute and Medical Center, Bharat Institute of Higher Education and Research, Chennai, India.
Institute of Liver Studies, King's College Hospital, London, UK.

Gonzalo Sapisochin (G)

Multi-Organ Transplant and HPB Surgical Oncology, Division of General Surgery, University Health Network, Department of Surgery, University of Toronto, Canada.

Kyung-Suk Suh (KS)

Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea.

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