Optical Quality in Keratoconus Is Associated With Corneal Biomechanics.
Aberrometry
Adolescent
Adult
Aged
Biomechanical Phenomena
/ physiology
Child
Cornea
/ physiopathology
Corneal Topography
Corneal Wavefront Aberration
/ physiopathology
Elasticity
/ physiology
Female
Humans
Keratoconus
/ physiopathology
Male
Middle Aged
Prospective Studies
Refraction, Ocular
/ physiology
Vision, Ocular
/ physiology
Visual Acuity
/ physiology
Journal
Cornea
ISSN: 1536-4798
Titre abrégé: Cornea
Pays: United States
ID NLM: 8216186
Informations de publication
Date de publication:
01 Oct 2021
01 Oct 2021
Historique:
received:
04
08
2020
accepted:
24
10
2020
pubmed:
18
12
2020
medline:
18
12
2021
entrez:
17
12
2020
Statut:
ppublish
Résumé
To evaluate the correlations between corneal biomechanical indices from dynamic Scheimpflug assessment and optical quality assessed as higher-order aberrations (HOAs) using a Hartmann-Shack ocular wavefront sensor in patients with keratoconus (KC). In this prospective, observational case series, the eyes with KC or KC suspect (KCS) from Osaka University Hospital, Osaka, Japan, were analyzed. Corneal biomechanical assessment was performed using Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany), and ocular wavefront aberrations were measured using the KR-1W (Topcon Corp, Tokyo, Japan). Correlations between the biomechanical indices and ocular HOAs were assessed. Corneal biomechanical indices included the deformation amplitude ratio within 2 mm, integrated radius, stiffness parameter at the first applanation, and the linear Corvis Biomechanical Index. Wavefront data of the central 4-mm region were expanded up to the sixth order of Zernike polynomials. The magnitudes of trefoil, coma, tetrafoil, secondary astigmatism, and spherical aberration were calculated by Zernike vector analysis and then used as ocular HOA parameters along with total HOAs. Thirty-four KC eyes and 37 KCS eyes were included. KC eyes showed significant correlations between ocular HOAs and biomechanics, whereas there were few significant correlations in KCS eyes. In KC eyes, deformation amplitude ratio within 2 mm, integrated radius, and Corvis Biomechanical Index beta showed stronger correlations with coma among the wavefront parameters. Corneal biomechanical indices correlated with ocular HOAs in patients with KC. In particular, there was a strong association with the increase in coma caused by inferosuperior asymmetry of the shape of the cornea in patients with KC.
Identifiants
pubmed: 33332893
doi: 10.1097/ICO.0000000000002631
pii: 00003226-202110000-00008
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1276-1281Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
R. Inoue is an employee of SEED CO., LTD. S. Koh and N. Maeda received fees from Oculus for a sponsored seminar not related to this article. R. Ambrósio is a consultant for Oculus. The remaining authors have no conflicts of interest to disclose.
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