Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear.
Journal
Biophysical journal
ISSN: 1542-0086
Titre abrégé: Biophys J
Pays: United States
ID NLM: 0370626
Informations de publication
Date de publication:
19 01 2021
19 01 2021
Historique:
received:
20
08
2020
revised:
19
11
2020
accepted:
30
11
2020
pubmed:
18
12
2020
medline:
15
5
2021
entrez:
17
12
2020
Statut:
ppublish
Résumé
The high sensitivity and effective frequency discrimination of sound detection performed by the auditory system rely on the dynamics of a system of hair cells. In the inner ear, these acoustic receptors are primarily attached to an overlying structure that provides mechanical coupling between the hair bundles. Although the dynamics of individual hair bundles has been extensively investigated, the influence of mechanical coupling on the motility of the system of bundles remains underdetermined. We developed a technique of mechanically coupling two active hair bundles, enabling us to probe the dynamics of the coupled system experimentally. We demonstrated that the coupling could enhance the coherence of hair bundles' spontaneous oscillation, as well as their phase-locked response to sinusoidal stimuli, at the calcium concentration in the surrounding fluid near the physiological level. The empirical data were consistent with numerical results from a model of two coupled nonisochronous oscillators, each displaying a supercritical Hopf bifurcation. The model revealed that a weak coupling can poise the system of unstable oscillators closer to the bifurcation by a shift in the critical point. In addition, the dynamics of strongly coupled oscillators far from criticality suggested that individual hair bundles may be regarded as nonisochronous oscillators. An optimal degree of nonisochronicity was required for the observed tuning behavior in the coherence of autonomous motion of the coupled system.
Identifiants
pubmed: 33333031
pii: S0006-3495(20)33201-X
doi: 10.1016/j.bpj.2020.11.2273
pmc: PMC7840414
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-216Informations de copyright
Copyright © 2020 Biophysical Society. Published by Elsevier Inc. All rights reserved.
Références
Proc Natl Acad Sci U S A. 2010 May 4;107(18):8079-84
pubmed: 20404191
Eur Phys J E Soft Matter. 2012 May;35(5):37
pubmed: 22623035
Neuron. 2012 Dec 6;76(5):989-97
pubmed: 23217746
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E1000-9
pubmed: 25691749
Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1943-8
pubmed: 22308449
Physiol Rev. 2001 Jul;81(3):1305-52
pubmed: 11427697
Neuron. 2008 May 8;58(3):333-9
pubmed: 18466744
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18669-74
pubmed: 19015514
Biophys J. 2018 Jan 23;114(2):425-436
pubmed: 29401440
Nat Rev Neurosci. 2014 Sep;15(9):600-14
pubmed: 25096182
PLoS One. 2015 Nov 05;10(11):e0141764
pubmed: 26540409
Biophys J. 2007 Dec 1;93(11):4053-67
pubmed: 17704173
Phys Rev Lett. 2016 Mar 11;116(10):108101
pubmed: 27015509
J R Soc Interface. 2013 Jul 24;10(87):20130525
pubmed: 23883956
Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1330-4
pubmed: 7679501
Nature. 2005 Feb 24;433(7028):880-3
pubmed: 15696193
Phys Rev E. 2018 Apr;97(4-1):042411
pubmed: 29758728
Phys Rev Lett. 2004 Oct 22;93(17):175702
pubmed: 15525091
J Neurosci. 2000 Oct 1;20(19):7131-42
pubmed: 11007868
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18651-2
pubmed: 19033193
Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14306-11
pubmed: 10588701
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12026-31
pubmed: 11027302
J Neurosci. 2003 Jun 1;23(11):4533-48
pubmed: 12805294
Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Apr;89(4):042703
pubmed: 24827274
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7185-90
pubmed: 24799674
Science. 1985 Jan 11;227(4683):194-6
pubmed: 3966153
Biophys J. 2011 Aug 3;101(3):603-10
pubmed: 21806928
Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12195-200
pubmed: 15302928
Sci Rep. 2019 Dec 5;9(1):18394
pubmed: 31804578
Biophys J. 2016 Aug 23;111(4):798-812
pubmed: 27558723
Biophys J. 2015 Jan 6;108(1):53-61
pubmed: 25564852