Regulatory effects of ghrelin on endoplasmic reticulum stress, oxidative stress, and autophagy: Therapeutic potential.
Autophagy
Diseases
Endoplasmic reticulum stress
Ghrelin
Oxidative stress
Journal
Neuropeptides
ISSN: 1532-2785
Titre abrégé: Neuropeptides
Pays: Netherlands
ID NLM: 8103156
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
27
09
2020
revised:
29
10
2020
accepted:
07
12
2020
pubmed:
18
12
2020
medline:
9
11
2021
entrez:
17
12
2020
Statut:
ppublish
Résumé
Ghrelin is a regulatory peptide that is the endogenous ligand of the growth hormone secretagogue 1a (GHS-R1a) which belongs to the G protein-coupled receptor family. Ghrelin and GHS-R1a are widely expressed in the central and peripheral tissues and play therapeutic potential roles in the cytoprotection of many internal organs. Endoplasmic reticulum stress (ERS), oxidative stress, and autophagy dysfunction, which are involved in various diseases. In recent years, accumulating evidence has suggested that ghrelin exerts protective effects by regulating ERS, oxidative stress, and autophagy in diverse diseases. This review article summarizes information about the roles of the ghrelin system on ERS, oxidative stress, and autophagy in multiple diseases. It is suggested that ghrelin positively affects the treatment of diseases and may be considered as a therapeutic drug in many illnesses.
Identifiants
pubmed: 33333485
pii: S0143-4179(20)30130-X
doi: 10.1016/j.npep.2020.102112
pii:
doi:
Substances chimiques
Ghrelin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102112Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.