Homeobox transcription factor engrailed homeobox 1 is a possible diagnostic marker for adenoid cystic carcinoma and polymorphous adenocarcinoma.
adenoid cystic carcinoma
engrailed homeobox 1
polymorphous adenocarcinoma
salivary gland tumor
Journal
Pathology international
ISSN: 1440-1827
Titre abrégé: Pathol Int
Pays: Australia
ID NLM: 9431380
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
14
09
2020
accepted:
06
11
2020
pubmed:
18
12
2020
medline:
26
10
2021
entrez:
17
12
2020
Statut:
ppublish
Résumé
Diagnostic utility of a homeobox transcription factor, engrailed homeobox 1 (En1) in the histopathology of salivary gland neoplasms was studied. The expression of En1 was immunohistochemically examined in 51 cases of adenoid cystic carcinoma (AdCC) and 143 cases of other salivary gland neoplasms. In all 51 AdCCs, En1 was expressed in 30-100% of tumor cells. In eight of nine polymorphous adenocarcinomas (PACs), En1 was expressed in 40-100% of tumor cells. Less than 5% of tumor cells expressed En1 in three of 12 epithelial-myoepithelial carcinomas, one of 17 basal cell adenomas (BCAs), and one of 34 pleomorphic adenomas (PAs). Among 55 other carcinoma cases, 1-30% of tumor cells expressed En1 in three salivary duct carcinomas (SDCs) ex PA. None of the myoepitheliomas and Warthin tumors expressed En1. When the cut-off value of the percentage of En1-expressing cells was set to 25%, all 51 AdCCs, eight of nine PACs and one SDC ex PA were En1-positive and the others were En1-negative. En1 is expressed consistently in AdCCs, frequently in PACs, but rarely in other salivary gland neoplasms. En1 is a possible diagnostic marker for AdCC and PAC in the histopathology of salivary gland neoplasms.
Substances chimiques
Biomarkers, Tumor
0
EN1 protein, human
0
Homeodomain Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113-123Informations de copyright
© 2020 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.
Références
Dillon PM, Chakraborty S, Moskaluk CA, Joshi PJ, Thomas CY. Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials. Head Neck 2016; 38: 620-7.
Seethala RR. Basaloid/blue salivary gland tumors. Mod Pathol 2017; 30: S84-95.
Azumi N, Battifora H. The cellular composition of adenoid cystic carcinoma. An immunohistochemical study. Cancer 1987; 60: 1589-98.
Hsieh MS, Lee YH, Chang YL. SOX10-positive salivary gland tumors: A growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma. Hum Pathol 2016; 56: 134-42.
Mino M, Pilch BZ, Faquin WC. Expression of KIT (CD117) in neoplasms of the head and neck: An ancillary marker for adenoid cystic carcinoma. Mod Pathol 2003; 16: 1224-31.
Brill LB, Kanner WA, Fehr A et al. Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol 2011; 24: 1169-76.
Rooney SL, Robinson RA. Immunohistochemical expression of MYB in salivary gland basal cell adenocarcinoma and basal cell adenoma. J Oral Pathol Med 2017; 46: 798-802.
Holland PW, Booth HA, Bruford EA. Classification and nomenclature of all human homeobox genes. BMC Biol 2007; 5: 47.
Hanks M, Wurst W, Anson-Cartwright L, Auerbach A, Joyner A. Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science. 1995; 269: 679-82.
Loomis CA, Harris E, Michaud J, Wurst W, Hanks M, Joyner AL. The mouse Engrailed-1 gene and ventral limb patterning. Nature. 1996; 382: 360-3.
Kamberov YG, Karlsson EK, Kamberova GL et al. A genetic basis of variation in eccrine sweat gland and hair follicle density. Proc Natl Acad Sci U S A 2015; 112: 9932-7.
Miura K, Akashi T, Ando N et al. Homeobox transcriptional factor engrailed homeobox 1 is expressed specifically in normal and neoplastic sweat gland cells. Histopathology. 2018; 72: 1199-208.
Prieto-Granada CN, Zhang L, Antonescu CR, Henneberry JM, Messina JL. Primary cutaneous adenoid cystic carcinoma with MYB aberrations: Report of three cases and comprehensive review of the literature. J Cutan Pathol 2017; 44: 201-9.
Ramakrishnan R, Chaudhry IH, Ramdial P et al. Primary cutaneous adenoid cystic carcinoma: A clinicopathologic and immunohistochemical study of 27 cases. Am J Surg Pathol 2013; 37: 1603-11.
Bell D, Bell A, Roberts D, Weber RS, El-Naggar AK. Developmental transcription factor EN1- A novel biomarker in human salivary gland adenoid cystic carcinoma. Cancer. 2012; 118: 1288-92.
Phuchareon J, Overdevest JB, McCormick F, Eisele DW, van Zante A, Tetsu O. Fatty acid binding protein 7 is a molecular marker in adenoid cystic carcinoma of the salivary glands: Implications for clinical significance. Transl Oncol 2014; 7: 780-7.
Ansai S, Koseki S, Hozumi Y, Kondo S. An immunohistochemical study of lysozyme, CD-15 (Leu M1), and gross cystic disease fluid protein-15 in various skin tumors. Assessment of the specificity and sensitivity of markers of apocrine differentiation. Am J Dermatopathol 1995; 17: 249-55.
Nagao T, Gaffey TA, Serizawa H et al. Dedifferentiated adenoid cystic carcinoma: A clinicopathologic study of 6 cases. Mod Pathol 2003; 16: 1265-72.
Bell D, Bell AH, Bondaruk J, Hanna EY, Weber RS. In-depth characterization of the salivary adenoid cystic carcinoma transcriptome with emphasis on dominant cell type. Cancer. 2016; 122: 1513-22.
Frerich CA, Brayer KJ, Painter BM et al. Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomes. Oncotarget. 2018; 9: 7341-58.
Wilson TC, Robinson RA. Basal cell adenocarcinoma and Basal cell adenoma of the salivary glands: A clinicopathological review of seventy tumors with comparison of morphologic features and growth control indices. Head Neck Pathol 2015; 9: 205-13.
Gary L, Ellis PLA. Tumors of the Salivary Gland, 4th ed. Wasington, DC: American Registry of Pathology, 2008.
Bishop JA, Westra WH. MYB translocation status in salivary gland epithelial-myoepithelial carcinoma: Evaluation of classic, variant, and hybrid forms. Am J Surg Pathol 2018; 42: 319-25.
Penner CR, Folpe AL, Budnick SD. C-kit expression distinguishes salivary gland adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. Mod Pathol 2002; 15: 687-91.
Sebastiao APM, Xu B, Lozada JR et al. Histologic spectrum of polymorphous adenocarcinoma of the salivary gland harbor genetic alterations affecting PRKD genes. Mod Pathol 2020; 33: 65-73.
Seethala RR, Barnes EL, Hunt JL. Epithelial-myoepithelial carcinoma: A review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol 2007; 31: 44-57.
West RB, Kong C, Clarke N et al. MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation. Am J Surg Pathol 2011; 35: 92-9.
Moon A, Cohen C, Siddiqui MT. MYB expression: Potential role in separating adenoid cystic carcinoma (ACC) from pleomorphic adenoma (PA). Diagn Cytopathol 2016; 44: 799-804.
Davis CA, Joyner AL. Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes Dev 1988; 2: 1736-44.
Miura K, Akashi T, Namiki T et al. Engrailed homeobox 1 and cytokeratin 19 are independent diagnostic markers of eccrine porocarcinoma and distinguish it from squamous cell carcinoma. Am J Clin Pathol 2020; 154: 499-509.
Beltran AS, Graves LM, Blancafort P. Novel role of engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function. Oncogene. 2014; 33: 4767-77.
Fagerberg L, Oksvold P, Skogs M et al. Contribution of antibody-based protein profiling to the human Chromosome-centric Proteome Project (C-HPP). J Proteome Res 2013; 12: 2439-48.
Drier Y, Cotton MJ, Williamson KE et al. An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet 2016; 48: 265-72.
Alvarez-Fischer D, Fuchs J, Castagner F et al. Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults. Nat Neurosci 2011; 14: 1260-6.
Prasad ML, Barbacioru CC, Rawal YB, Husein O, Wen P. Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Mod Pathol 2008; 21: 105-14.
Rozengurt E. Protein kinase D signaling: Multiple biological functions in health and disease. Physiology (Bethesda) 2011; 26: 23-33.
Asaithambi A, Ay M, Jin H et al. Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. PLoS One 2014; 9: e96947.
Spasojevic C, Marangoni E, Vacher S et al. PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer. Oncotarget. 2018; 9: 23208-19.
Danielian PS, McMahon AP. Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature. 1996; 383: 332-4.
Kim DY, Park EY, Chang E et al. A novel miR-34a target, protein kinase D1, stimulates cancer stemness and drug resistance through GSK3/beta-catenin signaling in breast cancer. Oncotarget. 2016; 7: 14791-802.
Williams L, Thompson LDR, Seethala RR et al. Salivary duct carcinoma: The predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression. Am J Surg Pathol 2015; 39: 705-13.
Montagna W. Histology and cytochemistry of human skin. XIX. The development and fate of the axillary organ. J Invest Dermatol 1959; 33: 151-61.
Hashimoto K, Gross BG, Lever WF. The ultrastructure of the skin of human embryos. I. The intraepidermal eccrine sweat duct. J Invest Dermatol 1965; 45: 139-51.
Schmidt LA, Olsen SH, McHugh JB. Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: A potential diagnostic pitfall that may be mistaken for malignancy. Am J Surg Pathol 2010; 34: 1205-10.
Lewis JE, Olsen KD, Sebo TJ. Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. Hum Pathol 2001; 32: 596-604.
Katabi N, Gomez D, Klimstra DS, Carlson DL, Lee N, Ghossein R. Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: A clinicopathologic study of 43 cases. Hum Pathol 2010; 41: 927-34.
Bahrami A, Perez-Ordonez B, Dalton JD, Weinreb I. An analysis of PLAG1 and HMGA2 rearrangements in salivary duct carcinoma and examination of the role of precursor lesions. Histopathology. 2013; 63: 250-62.
Shimura T, Tada Y, Hirai H et al. Prognostic and histogenetic roles of gene alteration and the expression of key potentially actionable targets in salivary duct carcinomas. Oncotarget. 2018; 9: 1852-67.