Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities.
molecular tumor board
next-generation sequencing
non-small cell lung cancer
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
15 Dec 2020
15 Dec 2020
Historique:
received:
16
11
2020
revised:
07
12
2020
accepted:
10
12
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
19
12
2020
Statut:
epublish
Résumé
Lung cancer remains the first cause of cancer-related deaths worldwide. Thanks to the improvement in the knowledge of the biology of non-small cell lung cancer (NSCLC), patients' survival has significantly improved. A growing number of targetable molecular alterations have been identified. Next-generation sequencing (NGS) has become one of the methodologies entered in clinical practice and was recently recommended by the European society for medical oncology (ESMO) to perform a comprehensive molecular characterization in patients with cancer. The current review provides an overview of the clinical trials that have explored the impact of NGS in patients with cancer, its limits, and advantages.
Identifiants
pubmed: 33333743
pii: diagnostics10121092
doi: 10.3390/diagnostics10121092
pmc: PMC7765222
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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