A Prospective Phase II Study Evaluating Intraoperative Electrochemotherapy of Hepatocellular Carcinoma.
bleomycin
electrochemotherapy
hepatocellular carcinoma
liver cancer
open surgery
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
15 Dec 2020
15 Dec 2020
Historique:
received:
06
11
2020
revised:
09
12
2020
accepted:
14
12
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
19
12
2020
Statut:
epublish
Résumé
The aim of this clinical study was to investigate the effectiveness and long-term safety of electrochemotherapy as an emerging treatment for HCC in patients not suitable for other treatment options. A prospective phase II clinical study was conducted in patients with primary HCC who were not suitable for other treatment options according to the Barcelona Clinic Liver Cancer classification. A total of 24 patients with 32 tumors were treated by electrochemotherapy. The procedure was effective, feasible, and safe with some procedure-related side effects. The responses of the 32 treated nodules were: 84.4% complete response (CR), 12.5% partial response (PR), and 3.1% stable disease (SD). The treatment was equally effective for nodules located centrally and peripherally. Electrochemotherapy provided a durable response with local tumor control over 50 months of observation in 78.0% of nodules. The patient responses were: 79.2% CR and 16.6% PR. The median progression-free survival was 12 months (range 2.7-50), and the overall survival over 5 years of observation was 72.0%. This prospective phase II clinical study showed that electrochemotherapy was an effective, feasible, and safe option for treating HCC in patients not suitable for other treatment options.
Identifiants
pubmed: 33333941
pii: cancers12123778
doi: 10.3390/cancers12123778
pmc: PMC7765454
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Slovenian Research Agency (ARRS),
ID : P3-0003 , P2-0249
Références
Radiol Oncol. 2016 Feb 16;50(1):1-13
pubmed: 27069444
Radiol Oncol. 2020 Jun 20;54(3):347-352
pubmed: 32562533
Bioelectricity. 2019 Dec 1;1(4):204-213
pubmed: 34471824
Semin Liver Dis. 2010 Feb;30(1):52-60
pubmed: 20175033
Cardiovasc Intervent Radiol. 2020 Jan;43(1):84-93
pubmed: 31385006
Basic Clin Pharmacol Toxicol. 2018 Sep;123(3):247-256
pubmed: 29573558
Radiol Oncol. 2015 Aug 21;49(3):234-41
pubmed: 26401128
Eur J Surg Oncol. 2020 Sep;46(9):1628-1633
pubmed: 32387070
J Am Coll Surg. 2012 Jul;215(1):19-28; discussion 28-30
pubmed: 22608403
Eur J Surg Oncol. 2019 Feb;45(2):92-102
pubmed: 30528893
J Vasc Interv Radiol. 2014 Jul;25(7):997-1011; quiz 1011
pubmed: 24656178
Cancer Immunol Immunother. 2016 Aug;65(8):951-9
pubmed: 27294607
Int J Hyperthermia. 2020;37(1):486-505
pubmed: 32423258
Lancet. 2012 Mar 31;379(9822):1245-55
pubmed: 22353262
Eur J Surg Oncol. 2018 May;44(5):651-657
pubmed: 29402556
Radiology. 2020 May;295(2):254-272
pubmed: 32208094
Liver Cancer. 2019 Nov;8(6):427-446
pubmed: 31799201
Acta Oncol. 2018 Jul;57(7):874-882
pubmed: 29577784
J Vasc Interv Radiol. 2011 Jul;22(7):947-51
pubmed: 21550820
Phys Med Biol. 2012 Sep 7;57(17):5425-40
pubmed: 22864181
Cardiovasc Intervent Radiol. 2019 Apr;42(4):577-583
pubmed: 30465255
Korean J Hepatobiliary Pancreat Surg. 2012 Aug;16(3):98-104
pubmed: 26388916
Dig Dis. 2009;27(2):142-7
pubmed: 19546552
Radiol Oncol. 2019 Oct 10;53(4):415-426
pubmed: 31600140
J Hepatol. 2012 Apr;56(4):908-43
pubmed: 22424438
Res Vet Sci. 2019 Feb;122:40-49
pubmed: 30453179
Eur J Cancer. 2020 Oct;138:30-40
pubmed: 32836172
Sci Rep. 2019 Mar 6;9(1):3649
pubmed: 30842517
Bioelectromagnetics. 2015 Dec;36(8):603-12
pubmed: 26508012
Vet Comp Oncol. 2017 Jun;15(2):641-654
pubmed: 26840222
Cancer Immunol Immunother. 2015 Oct;64(10):1315-27
pubmed: 26067277
Liver Cancer. 2015 Dec;4(4):208-14
pubmed: 26734576
J Hepatol. 2018 Jul;69(1):182-236
pubmed: 29628281
Clin Exp Metastasis. 2019 Aug;36(4):311-319
pubmed: 31134394
Hepatology. 1999 Jan;29(1):62-7
pubmed: 9862851
Clin Liver Dis. 2005 May;9(2):191-211, v
pubmed: 15831268
Liver Cancer. 2012 Nov;1(3-4):144-58
pubmed: 24159579
Int J Hyperthermia. 2018 Dec;34(8):1171-1178
pubmed: 29457510
J Hepatocell Carcinoma. 2017 Mar 13;4:49-58
pubmed: 28331845
Radiol Oncol. 2013 Mar;47(1):32-41
pubmed: 23450195
Radiol Oncol. 2018 Oct 18;52(4):383-391
pubmed: 30352044
Int J Hepatol. 2013;2013:174103
pubmed: 24369506
Clin Exp Metastasis. 2013 Jan;30(1):37-45
pubmed: 22735940
J Surg Oncol. 2014 Sep;110(3):320-7
pubmed: 24782355
Semin Oncol. 2019 Apr;46(2):173-191
pubmed: 31122761
Liver Cancer. 2016 Nov;6(1):44-50
pubmed: 27995087
Expert Rev Gastroenterol Hepatol. 2009 Aug;3(4):353-67
pubmed: 19673623
Technol Cancer Res Treat. 2011 Oct;10(5):475-85
pubmed: 21895032
PLoS One. 2017 Jul 7;12(7):e0180709
pubmed: 28686650
World J Gastroenterol. 2019 Apr 14;25(14):1653-1665
pubmed: 31011252