Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study.
Adipose Tissue
/ metabolism
Adult
Aged
Aged, 80 and over
Bone Neoplasms
/ secondary
Breast
/ metabolism
Breast Neoplasms
/ metabolism
Chromatography, Gas
Fatty Acids, Omega-3
/ metabolism
Female
Humans
Middle Aged
Neoplasm Metastasis
Phenotype
Postmenopause
/ metabolism
Premenopause
/ metabolism
Retrospective Studies
Risk Factors
adipose tissue
bone metastases
breast cancer
n-3 long-chain polyunsaturated fatty acids
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
15 Dec 2020
15 Dec 2020
Historique:
received:
09
10
2020
revised:
23
11
2020
accepted:
12
12
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
28
4
2021
Statut:
epublish
Résumé
In the present study, we investigated various biochemical, clinical, and histological factors associated with bone metastases in a large cohort of pre- and postmenopausal women with breast cancer. Two hundred and sixty-one consecutive women with breast cancer were included in this study. Breast adipose tissue specimens were collected during surgery. After having established the fatty acid profile of breast adipose tissue by gas chromatography, we determined whether there were differences associated with the occurrence of bone metastases in these patients. Regarding the clinical and histological criteria, a majority of the patients with bone metastases (around 70%) had tumors with a luminal phenotype and 59% of them showed axillary lymph node involvement. Moreover, we found a negative association between the levels of
Identifiants
pubmed: 33333962
pii: nu12123832
doi: 10.3390/nu12123832
pmc: PMC7765404
pii:
doi:
Substances chimiques
Fatty Acids, Omega-3
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Cell Physiol Biochem. 2017;41(2):722-730
pubmed: 28214830
J Inherit Metab Dis. 2010 Dec;33 Suppl 3:S363-71
pubmed: 20830525
PLoS One. 2012;7(12):e52838
pubmed: 23285198
Lipids. 2003 Jun;38(6):683-6
pubmed: 12934680
Cancer Metastasis Rev. 1989 Aug;8(2):98-101
pubmed: 2673568
Endocr Relat Cancer. 2016 Dec;23(12):R567-R576
pubmed: 27687494
Clin Cancer Res. 2014 Jun 1;20(11):2922-32
pubmed: 24687923
PLoS One. 2015 Apr 13;10(4):e0125145
pubmed: 25867515
Breast. 2013 Aug;22 Suppl 2:S50-6
pubmed: 24074793
Med Sci Monit. 2016 Jan 21;22:226-33
pubmed: 26795027
Prog Lipid Res. 2010 Oct;49(4):438-49
pubmed: 20600307
Int J Cancer. 2015 Aug 15;137(4):968-77
pubmed: 25603921
Biochem Biophys Res Commun. 2010 Nov 26;402(4):602-7
pubmed: 20971068
Cancer Lett. 2017 Aug 10;401:39-45
pubmed: 28527945
Sci Rep. 2020 Feb 6;10(1):1954
pubmed: 32029824
Int J Mol Sci. 2019 Apr 11;20(7):
pubmed: 30979019
Breast. 2019 Jun;45:113-117
pubmed: 30959386
Nat Med. 2012 Aug;18(8):1224-31
pubmed: 22820642
Cancer Cell. 2013 May 13;23(5):573-81
pubmed: 23680145
PLoS One. 2011 Apr 29;6(4):e19234
pubmed: 21559440
N Engl J Med. 2004 Apr 15;350(16):1655-64
pubmed: 15084698
Sci Adv. 2017 Nov 08;3(11):eaao1193
pubmed: 29134198
Nature. 2016 Jan 21;529(7586):298-306
pubmed: 26791720
Prog Lipid Res. 2008 Sep;47(5):348-80
pubmed: 18435934
Nat Rev Cancer. 2016 May 25;16(6):373-86
pubmed: 27220481
Nutrients. 2014 Jul 09;6(7):2584-601
pubmed: 25010555
Adv Nutr. 2012 Mar 01;3(2):127-34
pubmed: 22516720
Cancer Lett. 1997 Jan 1;111(1-2):179-85
pubmed: 9022144
N Engl J Med. 2005 Aug 25;353(8):793-802
pubmed: 16120859
Am J Clin Nutr. 2010 May;91(5):1185-94
pubmed: 20335550
Nutr Metab (Lond). 2011 Jan 27;8:5
pubmed: 21272363
J Exp Clin Cancer Res. 2017 Aug 11;36(1):108
pubmed: 28800754
JAMA Netw Open. 2019 Mar 1;2(3):e190429
pubmed: 30848812
Br J Cancer. 2020 Jan;122(1):4-22
pubmed: 31819192
Carcinogenesis. 2012 Oct;33(10):1897-908
pubmed: 22678116
BMJ. 2013 Jun 27;346:f3706
pubmed: 23814120
Am J Clin Nutr. 1980 Jan;33(1):81-5
pubmed: 7355785
Nutrients. 2014 Nov 18;6(11):5184-223
pubmed: 25412153
Crit Rev Food Sci Nutr. 2017 Jul 24;57(11):2245-2262
pubmed: 25897862
Clin Exp Metastasis. 2018 Dec;35(8):797-818
pubmed: 30327985
Mol Cell Biochem. 2002 Oct;239(1-2):45-54
pubmed: 12479567
Oncotarget. 2017 Apr 25;8(17):29487-29500
pubmed: 28412757
Eur J Nutr. 2020 Aug;59(5):2089-2097
pubmed: 31350637
Ecancermedicalscience. 2017 Jan 24;11:715
pubmed: 28194227
Adv Nutr. 2016 Mar 15;7(2):299-312
pubmed: 26980813
Mol Cancer Res. 2009 Jul;7(7):1013-20
pubmed: 19567784
J Biol Chem. 1996 Oct 4;271(40):24711-9
pubmed: 8798739
Exp Ther Med. 2018 Feb;15(2):1167-1176
pubmed: 29434704
Prostaglandins Other Lipid Mediat. 2014 Oct;113-115:13-20
pubmed: 25019221
Eur J Clin Nutr. 1997 Sep;51(9):619-24
pubmed: 9306089
Cancer Cell. 2003 Jun;3(6):537-49
pubmed: 12842083
Lancet. 2015 Oct 3;386(10001):1353-1361
pubmed: 26211824
Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E577-88
pubmed: 14600072
Br J Nutr. 2010 Sep;104(5):674-85
pubmed: 20420751
Curr Opin Lipidol. 2006 Feb;17(1):22-7
pubmed: 16407712
Genes Nutr. 2014 Jul;9(4):409
pubmed: 24895107
Proc Nutr Soc. 1999 Aug;58(3):633-46
pubmed: 10604197
Cancer Res. 2010 Jul 15;70(14):5649-69
pubmed: 20610625
Breast Cancer Res Treat. 2013 Oct;141(3):341-52
pubmed: 24062211
Front Endocrinol (Lausanne). 2019 Mar 15;10:157
pubmed: 30949128
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Biochimie. 2019 Apr;159:36-48
pubmed: 30716358
BMC Cancer. 2016 May 12;16:307
pubmed: 27175930
Annu Rev Nutr. 2013;33:319-48
pubmed: 23701588