T-cell receptor repertoire of cytomegalovirus-specific cytotoxic T-cells after allogeneic stem cell transplantation.
Adult
Aged
Biomarkers
Clonal Evolution
Cytomegalovirus
/ immunology
Cytomegalovirus Infections
/ etiology
Disease Susceptibility
/ immunology
Female
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Immunophenotyping
Male
Middle Aged
Receptors, Antigen, T-Cell
/ genetics
T-Cell Antigen Receptor Specificity
T-Lymphocytes, Cytotoxic
/ immunology
Transplantation Immunology
Transplantation, Homologous
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 12 2020
17 12 2020
Historique:
received:
28
05
2020
accepted:
08
12
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
11
5
2021
Statut:
epublish
Résumé
Cytomegalovirus (CMV) infection is a major complication during allogeneic stem cell transplantation (allo-SCT). However, mechanisms of adaptive immunity that drive this remain unclear. To define early immunological responses to CMV after transplantation, we using next-generation sequencing to examine the repertoire of T-cell receptors in CD8
Identifiants
pubmed: 33335252
doi: 10.1038/s41598-020-79363-2
pii: 10.1038/s41598-020-79363-2
pmc: PMC7747720
doi:
Substances chimiques
Biomarkers
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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