Locally Advanced Pancreatic Ductal Adenocarcinoma: Challenges and Progress.
hadrontherapy
pancreatic cancer
risk factors
surgery
treatment
Journal
OncoTargets and therapy
ISSN: 1178-6930
Titre abrégé: Onco Targets Ther
Pays: New Zealand
ID NLM: 101514322
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
08
2020
accepted:
30
11
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
19
12
2020
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is one of the major causes of death in the Western world, and it is estimated to become the second leading cause of tumour-related mortality in the next 10 years. Among pancreatic cancers, ductal adenocarcinomas are by far the most common, characterised by a challenging diagnosis due to the lack of initial and pathognomonic clinical signs. In this scenario, non-metastatic locally advanced pancreatic cancer (LAPC) accounts for a large proportion of all new pancreatic ductal adenocarcinoma diagnoses. There is no consensus on a common definition of LAPC. Still, it usually includes tumours that are not resectable due to vascular involvement. As of today, treatment is limited, and the prognosis is very unfavourable. Curative-intent surgery remains the gold-standard even if often jeopardized by vascular involvement. Continuing progress in our understanding of LAPC genetics and immunology will permit the development of different treatments, targeted or combined, including radiation therapy, hadrontherapy, targeted immunotherapies or new chemotherapies. A multidisciplinary approach combining various fields of expertise is essential in aiming to limit disease progression as well as patient outcome. Using a narrative literature review approach, the manuscript explores the most up-to-date knowledge concerning locally advanced pancreatic ductal adenocarcinoma management.
Identifiants
pubmed: 33335406
doi: 10.2147/OTT.S220971
pii: 220971
pmc: PMC7737010
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
12705-12720Informations de copyright
© 2020 Barcellini et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest for this work.
Références
In Vivo. 2019 Mar-Apr;33(2):529-533
pubmed: 30804137
J Natl Compr Canc Netw. 2019 Mar 1;17(3):202-210
pubmed: 30865919
Br J Surg. 2006 Dec;93(12):1446-55
pubmed: 17115408
Ann Surg Oncol. 2006 Aug;13(8):1035-46
pubmed: 16865597
J Med Genet. 2006 Apr;43(4):e15
pubmed: 16582077
Anticancer Res. 2020 Mar;40(3):1645-1649
pubmed: 32132069
Insights Imaging. 2020 Apr 25;11(1):58
pubmed: 32335790
Diagn Cytopathol. 2020 Dec;48(12):1230-1236
pubmed: 32770823
BMC Cancer. 2019 Sep 14;19(1):922
pubmed: 31521134
Radiother Oncol. 2012 Apr;103(1):25-31
pubmed: 22300608
Acta Cytol. 2020;64(4):344-351
pubmed: 31550713
Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):918-25
pubmed: 25585785
Cancer Causes Control. 2010 Aug;21(8):1305-14
pubmed: 20383573
Sci Rep. 2017 Jun 9;7(1):3165
pubmed: 28600530
Oncology. 2020;98(8):513-519
pubmed: 32408297
Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21727-21731
pubmed: 31591243
Future Oncol. 2019 Sep;15(26):3081-3095
pubmed: 31426679
World J Gastroenterol. 2014 Aug 28;20(32):11182-98
pubmed: 25170203
Br J Surg. 2008 Dec;95(12):1449-61
pubmed: 18991254
Ann Oncol. 2010 May;21 Suppl 5:v55-8
pubmed: 20555103
Int J Cancer. 2018 Aug 15;143(4):801-812
pubmed: 29524225
Transplant Proc. 2009 Jan-Feb;41(1):354-5
pubmed: 19249556
Onco Targets Ther. 2019 May 06;12:3387-3400
pubmed: 31118690
Cancers (Basel). 2017 Apr 28;9(5):
pubmed: 28452926
Arch Intern Med. 2010 May 10;170(9):791-802
pubmed: 20458087
Oncology. 2020 Oct 8;:1-7
pubmed: 33032278
World J Gastroenterol. 2018 May 21;24(19):2047-2060
pubmed: 29785074
BMC Cancer. 2018 Jun 25;18(1):688
pubmed: 29940910
Cancer. 2011 Feb 1;117(3):642-7
pubmed: 20824626
Surg Today. 2015 Mar;45(3):297-304
pubmed: 24973941
CA Cancer J Clin. 1994 Sep-Oct;44(5):304-18
pubmed: 7521272
Pancreas. 2011 Mar;40(2):265-70
pubmed: 21404460
Sci Rep. 2017 Feb 01;7:41064
pubmed: 28145465
Int J Radiat Oncol Biol Phys. 2016 Mar 15;94(4):755-65
pubmed: 26972648
Endocr Relat Cancer. 2012 Sep 05;19(5):F9-F26
pubmed: 22843556
Lancet. 2008 Feb 16;371(9612):569-78
pubmed: 18280327
Int J Biol Sci. 2016 Jan 28;12(3):314-25
pubmed: 26929738
Anticancer Res. 2019 Feb;39(2):909-913
pubmed: 30711975
CA Cancer J Clin. 2013 Sep;63(5):318-48
pubmed: 23856911
Endocr Rev. 2009 Oct;30(6):586-623
pubmed: 19752219
J Gastroenterol. 2014 Jun;49(6):1074-80
pubmed: 23846547
J Cancer Educ. 2020 Nov 9;:
pubmed: 33169335
Ann Surg Oncol. 2014 Jul;21(7):2453-62
pubmed: 24609291
Dig Surg. 2016;33(4):343-50
pubmed: 27216011
J Am Coll Surg. 2008 Aug;207(2):210-8
pubmed: 18656049
Nature. 2016 Mar 3;531(7592):47-52
pubmed: 26909576
Carcinogenesis. 2014 Jul;35(7):1441-50
pubmed: 24743516
Nutr Cancer. 2013;65(1):157-64
pubmed: 23368926
JAMA. 2016 May 3;315(17):1844-53
pubmed: 27139057
Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):498-504
pubmed: 26883565
Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):320-3
pubmed: 16168826
Cancer Res. 2006 Aug 1;66(15):7810-7
pubmed: 16885385
Gut. 2010 Jul;59(7):975-86
pubmed: 20581245
Cell Transplant. 2012;21(7):1349-60
pubmed: 22305457
Cancer Res. 2014 Jun 1;74(11):2913-21
pubmed: 24840647
Anticancer Res. 2020 May;40(5):2853-2859
pubmed: 32366434
Am J Clin Oncol. 2018 Jul;41(7):656-661
pubmed: 28134673
BMC Cancer. 2014 Aug 28;14:624
pubmed: 25164437
Nat Genet. 2015 Oct;47(10):1168-78
pubmed: 26343385
PLoS Med. 2010 Apr 20;7(4):e1000267
pubmed: 20422030
Cancer Res. 2016 Dec 1;76(23):6851-6863
pubmed: 27742686
Cancer. 2013 Jan 1;119(1):45-51
pubmed: 22744973
J Surg Case Rep. 2018 Aug 30;2018(8):rjy218
pubmed: 30181863
Ann Oncol. 2012 Jul;23(7):1880-8
pubmed: 22104574
Cancer. 2012 Jan 15;118(2):493-9
pubmed: 21598239
Pancreas. 2016 Feb;45(2):311-6
pubmed: 26646264
Pract Radiat Oncol. 2016 Mar-Apr;6(2):78-85
pubmed: 26577010
Pancreas. 2015 Apr;44(3):512-3
pubmed: 25760285
Ann N Y Acad Sci. 2006 Oct;1079:383-98
pubmed: 17130583
Cancer Med. 2020 Jul;9(13):4572-4580
pubmed: 32368871
Mod Pathol. 2012 Mar;25(3):439-48
pubmed: 22056954
Am J Pathol. 2000 May;156(5):1641-51
pubmed: 10793075
Eur J Epidemiol. 2015 Apr;30(4):279-98
pubmed: 25773752
World J Gastroenterol. 2014 Jun 28;20(24):7864-77
pubmed: 24976723
Surgery. 2011 Sep;150(3):466-73
pubmed: 21878232
Anticancer Drugs. 2009 Aug;20(7):634-8
pubmed: 19433978
Pancreatology. 2020 Sep;20(6):1131-1138
pubmed: 32739267
Transl Gastroenterol Hepatol. 2019 Jun 27;4:50
pubmed: 31304427
Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):678-86
pubmed: 18395362
Am J Epidemiol. 2009 Aug 15;170(4):403-13
pubmed: 19561064
J Surg Res. 2012 May 15;174(2):319-25
pubmed: 21937061
Radiother Oncol. 2019 Jul;136:37-43
pubmed: 31015127
Radiother Oncol. 2018 Nov;129(2):333-339
pubmed: 30224179
Scand J Surg. 2020 Mar;109(1):18-28
pubmed: 31960765
Nat Med. 2011 Apr;17(4):500-3
pubmed: 21460848
J Pediatr Genet. 2016 Jun;5(2):78-83
pubmed: 27617147
J Clin Oncol. 2015 Oct 1;33(28):3124-9
pubmed: 25940717
ISRN Oncol. 2013 May 30;2013:697521
pubmed: 23819063
J Surg Res. 2013 Sep;184(1):304-11
pubmed: 23866788
J Clin Med. 2020 Feb 28;9(3):
pubmed: 32121198
World J Surg. 2003 Oct;27(10):1075-84
pubmed: 12925907
Mol Carcinog. 2012 Jan;51(1):53-63
pubmed: 22162231
Lancet Oncol. 2016 Jun;17(6):801-810
pubmed: 27160474
Ann Surg. 2016 Sep;264(3):457-63
pubmed: 27355262
Anticancer Res. 2019 Sep;39(9):4613-4617
pubmed: 31519558
Cancer Biol Ther. 2011 Aug 1;12(3):165-8
pubmed: 21613821
Lancet. 2011 Aug 13;378(9791):607-20
pubmed: 21620466
Pancreatology. 2020 Jul;20(5):1004-1005
pubmed: 32418757
Ann Oncol. 2008 Sep;19(9):1592-9
pubmed: 18467316
J Clin Oncol. 1997 Jun;15(6):2403-13
pubmed: 9196156
J Clin Oncol. 2008 Feb 20;26(6):833-4
pubmed: 18281653
Oncotarget. 2017 Feb 7;8(6):9587-9596
pubmed: 28077783
Clin Transl Radiat Oncol. 2019 Apr 25;18:128-130
pubmed: 31341988
Nat Rev Clin Oncol. 2010 Jan;7(1):37-43
pubmed: 19949433
J Gastroenterol. 2013 Apr;48(4):544-8
pubmed: 23435671
In Vivo. 2020 May-Jun;34(3):1547-1553
pubmed: 32354961
J Cancer. 2017 Oct 11;8(18):3667-3674
pubmed: 29151953
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
CA Cancer J Clin. 2017 Jan;67(1):7-30
pubmed: 28055103
Endosc Ultrasound. 2017 Dec;6(Suppl 3):S76-S78
pubmed: 29387696
Pancreas. 2017 Mar;46(3):335-340
pubmed: 28099251
Gut. 2007 Oct;56(10):1460-9
pubmed: 17872573
Br J Radiol. 2017 Apr;90(1072):20160790
pubmed: 28181819
Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1212-1221
pubmed: 29907490
Genet Epidemiol. 2002 Aug;23(2):133-49
pubmed: 12214307
World J Gastroenterol. 2016 Nov 28;22(44):9694-9705
pubmed: 27956793
Gastroenterol Hepatol. 2016 Aug-Sep;39(7):481-93
pubmed: 26916701
Ann Epidemiol. 2013 Mar;23(3):124-8
pubmed: 23332711
Cancer Manag Res. 2019 Sep 09;11:8257-8268
pubmed: 31571983
Nat Genet. 2009 Jan;41(1):112-7
pubmed: 19098912
Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2298-306
pubmed: 20699371
Clin Cancer Res. 2009 Jul 15;15(14):4674-9
pubmed: 19584151