Icariin Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension via the Inhibition of TGF-
Journal
Evidence-based complementary and alternative medicine : eCAM
ISSN: 1741-427X
Titre abrégé: Evid Based Complement Alternat Med
Pays: United States
ID NLM: 101215021
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
05
2020
accepted:
24
11
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
19
12
2020
Statut:
epublish
Résumé
Pulmonary artery remodeling is important in the development of pulmonary artery hypertension. The TGF- Rats were randomly divided into control, monocrotaline (MCT), MCT + ICA-low, and MCT + ICA-high groups. MCT (60 mg/kg) was subcutaneously injected to induce PAH, and icariin (50 or 100 mg/kg.d) was orally administered for 2 weeks. At the end of the fourth week, right ventricular systolic pressure (RVSP) was obtained and the right ventricular hypertrophy index (RI) was determined as the ratio of the right ventricular weight to the left ventricular plus septal weight (RV/LV + S). Western blots were used to determine the expression of TGF- Compared to the control group, RVSP and RI were increased in the MCT group (
Sections du résumé
BACKGROUND
BACKGROUND
Pulmonary artery remodeling is important in the development of pulmonary artery hypertension. The TGF-
METHODS
METHODS
Rats were randomly divided into control, monocrotaline (MCT), MCT + ICA-low, and MCT + ICA-high groups. MCT (60 mg/kg) was subcutaneously injected to induce PAH, and icariin (50 or 100 mg/kg.d) was orally administered for 2 weeks. At the end of the fourth week, right ventricular systolic pressure (RVSP) was obtained and the right ventricular hypertrophy index (RI) was determined as the ratio of the right ventricular weight to the left ventricular plus septal weight (RV/LV + S). Western blots were used to determine the expression of TGF-
RESULTS
RESULTS
Compared to the control group, RVSP and RI were increased in the MCT group (
Identifiants
pubmed: 33335559
doi: 10.1155/2020/9238428
pmc: PMC7723481
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9238428Informations de copyright
Copyright © 2020 Yijia Xiang et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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