Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
10 Dec 2020
10 Dec 2020
Historique:
received:
04
08
2020
accepted:
14
10
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
19
12
2020
Statut:
epublish
Résumé
In recent years, novel bacterial topoisomerase inhibitors (NBTIs) have been developed as future antibacterials for treating multidrug-resistant bacterial infections. A series of dioxane-linked NBTIs with an amide moiety has been synthesized and evaluated. Compound
Identifiants
pubmed: 33335666
doi: 10.1021/acsmedchemlett.0c00428
pmc: PMC7734797
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2446-2454Informations de copyright
© 2020 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare the following competing financial interest(s): M.M.F. is a shareholder of Pfizer, Inc.
Références
Bioorg Med Chem Lett. 2017 Aug 1;27(15):3353-3358
pubmed: 28610977
Bioorg Med Chem Lett. 2007 May 15;17(10):2718-22
pubmed: 17382544
Biochemistry. 2019 Nov 5;58(44):4447-4455
pubmed: 31617352
J Med Chem. 2020 Jun 11;63(11):5664-5674
pubmed: 32027491
ACS Infect Dis. 2018 Aug 10;4(8):1211-1222
pubmed: 29746087
ACS Infect Dis. 2019 Jul 12;5(7):1115-1128
pubmed: 31041863
Bioorg Med Chem Lett. 2015 Sep 1;25(17):3636-43
pubmed: 26141771
Bioorg Med Chem Lett. 2018 Aug 1;28(14):2477-2480
pubmed: 29871847
Nature. 2000 Jun 22;405(6789):962-6
pubmed: 10879539
J Med Chem. 2019 Aug 22;62(16):7445-7472
pubmed: 31276392
Clin Infect Dis. 2019 Mar 5;68(6):1058-1062
pubmed: 30060092
J Med Chem. 2014 Jun 12;57(11):4889-905
pubmed: 24809953
N Engl J Med. 2020 Apr 2;382(14):1309-1319
pubmed: 32242356
Antimicrob Agents Chemother. 2017 May 24;61(6):
pubmed: 28373199
Nature. 2010 Aug 19;466(7309):935-40
pubmed: 20686482
J Biol Chem. 1998 Oct 16;273(42):27668-77
pubmed: 9765303
Antimicrob Agents Chemother. 2015 Sep;59(9):5278-87
pubmed: 26077256
Bioorg Med Chem Lett. 2007 May 15;17(10):2723-7
pubmed: 17368897
Bioorg Med Chem Lett. 2014 Feb 1;24(3):780-5
pubmed: 24433862
J Med Chem. 2004 Mar 25;47(7):1739-49
pubmed: 15027865
Future Med Chem. 2018 Oct 1;10(19):2241-2244
pubmed: 30215281
Bioorg Med Chem Lett. 2015 Jun 15;25(12):2473-8
pubmed: 25978963
Plasmid. 1983 Mar;9(2):182-90
pubmed: 6344110
Bioorg Med Chem Lett. 2013 May 15;23(10):2955-61
pubmed: 23566517
Clin Infect Dis. 2020 Apr 10;70(8):1758-1760
pubmed: 31412357
J Med Chem. 2015 Jan 22;58(2):927-42
pubmed: 25494934
ACS Infect Dis. 2020 Jun 12;6(6):1317-1322
pubmed: 32202756
ACS Infect Dis. 2019 Apr 12;5(4):570-581
pubmed: 30757898
J Mol Biol. 2019 Aug 23;431(18):3427-3449
pubmed: 31301408
Bioorg Med Chem. 2014 Oct 1;22(19):5392-409
pubmed: 25155913
Antimicrob Agents Chemother. 2016 Jan 04;60(3):1918-23
pubmed: 26729499
Biochem Pharmacol. 2012 Oct 1;84(7):900-4
pubmed: 22820247
Eur J Med Chem. 2020 Aug 1;199:112324
pubmed: 32402932
Lancet Infect Dis. 2018 Mar;18(3):318-327
pubmed: 29276051
Chem Rev. 2014 Feb 26;114(4):2313-42
pubmed: 24313284
Int J Mol Sci. 2018 Feb 03;19(2):
pubmed: 29401640
Lancet Infect Dis. 2009 Jun;9(6):384-92
pubmed: 19467478
Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49
pubmed: 18625781
J Med Chem. 2013 Sep 26;56(18):7396-415
pubmed: 23968485
J Med Chem. 2012 Aug 9;55(15):6916-33
pubmed: 22779424