Hepatopulmonary Syndrome and Post-Liver Transplantation Complications: A Case-Control Study.
Hepatopulmonary syndrome
Liver cirrhosis
Liver transplantation
Post-operative complications
Journal
International journal of organ transplantation medicine
ISSN: 2008-6482
Titre abrégé: Int J Organ Transplant Med
Pays: Iran
ID NLM: 101535773
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
19
12
2020
Statut:
ppublish
Résumé
Although liver transplantation (LT) improves survival in cirrhotic patients with hepatopulmonary syndrome (HPS), few data exist concerning post-operative complications in these patients. To compare complications after LT between patients with and without HPS. In a case-control study, we retrospectively analyzed all patients who underwent LT in our center from January 2010 to July 2016. We compared cases of identified HPS to controls matched for age, MELD score, comorbidities, red blood cells transfused, and highest dosage of norepinephrine perfused during transplantation. Among 451 transplanted patients, we identified 71 patients with HPS who could be analyzed. We found a significantly (p<0.001) higher number of post-operative complications in patients with HPS (median 5 HPS patients seem to have a higher number of complications in the first month following LT.
Sections du résumé
BACKGROUND
BACKGROUND
Although liver transplantation (LT) improves survival in cirrhotic patients with hepatopulmonary syndrome (HPS), few data exist concerning post-operative complications in these patients.
OBJECTIVE
OBJECTIVE
To compare complications after LT between patients with and without HPS.
METHODS
METHODS
In a case-control study, we retrospectively analyzed all patients who underwent LT in our center from January 2010 to July 2016. We compared cases of identified HPS to controls matched for age, MELD score, comorbidities, red blood cells transfused, and highest dosage of norepinephrine perfused during transplantation.
RESULTS
RESULTS
Among 451 transplanted patients, we identified 71 patients with HPS who could be analyzed. We found a significantly (p<0.001) higher number of post-operative complications in patients with HPS (median 5
CONCLUSION
CONCLUSIONS
HPS patients seem to have a higher number of complications in the first month following LT.
Types de publication
Journal Article
Langues
eng
Pagination
166-175Références
West J Med. 1995 Aug;163(2):133-8
pubmed: 7571560
Wound Repair Regen. 2015 Sep;23(5):664-71
pubmed: 26174572
Chest. 1997 May;111(5):1236-40
pubmed: 9149575
World J Gastroenterol. 2006 Sep 28;12(36):5878-83
pubmed: 17007057
Hepatology. 2005 May;41(5):1122-9
pubmed: 15828054
Liver Transpl. 2004 Feb;10(2):174-82
pubmed: 14762853
Transplant Proc. 2000 Nov;32(7):2177-8
pubmed: 11120121
Eur Respir J. 2004 Nov;24(5):861-80
pubmed: 15516683
Transplantation. 2003 May 15;75(9):1482-9; discussion 1446-7
pubmed: 12792501
J Bras Pneumol. 2010 Jul-Aug;36(4):432-40
pubmed: 20835589
Transplantation. 1999 Mar 15;67(5):712-7
pubmed: 10096527
Hepatology. 2013 Jun;57(6):2427-35
pubmed: 22996424
Thorax. 1992 Nov;47(11):897-902
pubmed: 1465744
Chest. 1981 Nov;80(5):570-4
pubmed: 7297148
Gastroenterology. 2003 Oct;125(4):1042-52
pubmed: 14517788
Transplant Proc. 2004 Nov;36(9):2762-3
pubmed: 15621142
Mol Cells. 2014 Sep;37(9):637-43
pubmed: 24957212
Eur Respir J. 1991 Jun;4(6):711-7
pubmed: 1889498
N Engl J Med. 2008 May 29;358(22):2378-87
pubmed: 18509123
Am J Transplant. 2006 Apr;6(4):783-90
pubmed: 16539636
Arq Gastroenterol. 2008 Jan-Mar;45(1):34-7
pubmed: 18425226
Antimicrob Agents Chemother. 2012 Apr;56(4):2114-8
pubmed: 22290986
Hepatology. 2003 Jan;37(1):192-7
pubmed: 12500204
Am J Transplant. 2010 Feb;10(2):354-63
pubmed: 19775311
Circulation. 2009 Sep 29;120(13):1189-94
pubmed: 19752326
Respiration. 2015;89(2):112-8
pubmed: 25613049
Transplant Proc. 2008 Dec;40(10):3512-6
pubmed: 19100426
Clin Transplant. 2013 Jul-Aug;27(4):530-4
pubmed: 23721501