Quinazolinones as Competitive Inhibitors of Carbonic Anhydrase-II (Human and Bovine): Synthesis,
bovine carbonic anhydrase-II
human carbonic anhydrase-II
kinetics
molecular docking
quinazolinones
structure-activity relationship
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
08
2020
accepted:
28
10
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
19
12
2020
Statut:
epublish
Résumé
Carbonic anhydrase-II (CA-II) is associated with glaucoma, malignant brain tumors, and renal, gastric, and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. CA-II inhibitors can be used to reduce the intraocular pressure usually associated with glaucoma. In search of potent CA-II inhibitors, a series of quinazolinones derivatives (
Identifiants
pubmed: 33335888
doi: 10.3389/fchem.2020.598095
pmc: PMC7736042
doi:
Types de publication
Journal Article
Langues
eng
Pagination
598095Informations de copyright
Copyright © 2020 Khan, Khan, Halim, Khan, Shafiq and Al-Harrasi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling Editor declared a past co-authorship with one of the authors with the authors AK, SH, and AA-H.
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