Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2.
COVID-19
D614G
MIS-C
SARS-CoV-2
pseudotumor cerebri syndrome
viral lineage
Journal
Journal of the Pediatric Infectious Diseases Society
ISSN: 2048-7207
Titre abrégé: J Pediatric Infect Dis Soc
Pays: England
ID NLM: 101586049
Informations de publication
Date de publication:
28 May 2021
28 May 2021
Historique:
received:
09
09
2020
accepted:
14
12
2020
pubmed:
19
12
2020
medline:
4
6
2021
entrez:
18
12
2020
Statut:
ppublish
Résumé
Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe to be the earliest case of MIS-C, occurring in February 2020. Our patient's SARS-CoV-2 infection was caused by an emerging lineage with the D614G variant in the spike protein. This lineage would subsequently become the predominant cause of SARS-CoV-2 outbreaks in Europe and the United States where MIS-C was first described.
Identifiants
pubmed: 33336251
pii: 6041189
doi: 10.1093/jpids/piaa167
pmc: PMC7799015
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
695-697Informations de copyright
Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society 2020.