Disseminated Mycobacterium marinum in Human Immunodeficiency Virus Unmasked by Immune Reconstitution Inflammatory Syndrome.
Mycobacterium marinum
HIV
IRIS
whole genome sequencing
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
02 08 2021
02 08 2021
Historique:
received:
20
10
2020
accepted:
16
12
2020
pubmed:
19
12
2020
medline:
15
12
2021
entrez:
18
12
2020
Statut:
ppublish
Résumé
Distinguishing disseminated Mycobacterium marinum from multifocal cutaneous disease in persons with human immunodeficiency virus/AIDS can present a diagnostic challenge, especially in the context of immune reconstitution inflammatory syndrome (IRIS). In this work, we demonstrate the utility of flow cytometry and whole genome sequencing (WGS) to diagnose disseminated M. marinum unmasked by IRIS following initiation of antiretroviral therapy. Flow cytometry demonstrated robust cytokine production by CD4 T cells in response to stimulation with M. marinum lysate. WGS of isolates from distinct lesions was consistent with clonal dissemination, supporting that preexisting disseminated M. marinum disease was uncovered by inflammatory manifestations, consistent with unmasking mycobacterial IRIS.
Identifiants
pubmed: 33336253
pii: 6041190
doi: 10.1093/infdis/jiaa769
pmc: PMC8328204
doi:
Banques de données
ClinicalTrials.gov
['NCT02147405']
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
453-457Informations de copyright
Published by Oxford University Press for the Infectious Diseases Society of America 2020.
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