Circadian effects on stroke outcome - Did we not wake up in time for neuroprotection?

Animals Blood Pressure Circadian Clocks / physiology Circadian Rhythm Disease Models, Animal Leukocytes / cytology Neuroprotection Stroke / pathology
Stroke animal models chronobiology. translational research neuroprotection

Journal

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566

Informations de publication

Date de publication:
03 2021
Historique:
pubmed: 19 12 2020
medline: 15 7 2021
entrez: 18 12 2020
Statut: ppublish

Résumé

The occurrence of stroke in humans peaks in the morning. A recent study revealed that time of day mitigates the therapeutic impact of neuroprotective paradigms. These findings might not only explain the previous failure of translation of neuroprotective therapies but inspire new paradigms in stroke chronopathophysiology research. Taking chronotype into account may complement the many factors that influence efficacy of experimental therapies in stroke.

Identifiants

DOI: 10.1177/0271678X20978711 PMID: 33337257 PMC: PMC7907996
pubmed: 33337257
doi: 10.1177/0271678X20978711
pmc: PMC7907996
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

684-686

Références

J Cereb Blood Flow Metab. 2018 Dec;38(12):2073-2091
pubmed: 30191760
J Cereb Blood Flow Metab. 2019 Jul;39(7):1394-1409
pubmed: 29972653
Circ Res. 2017 Jun 9;120(12):1916-1926
pubmed: 28373349
J Clin Invest. 2013 Dec;123(12):5389-400
pubmed: 24270424
J Cereb Blood Flow Metab. 2019 Sep;39(9):1661-1663
pubmed: 30351184
J Cereb Blood Flow Metab. 2017 Aug;37(8):2806-2819
pubmed: 27798273
Stroke. 2019 Nov;50(11):3299-3306
pubmed: 31658004
Nature. 2020 Jun;582(7812):395-398
pubmed: 32494010
J Cereb Blood Flow Metab. 2019 Mar;39(3):375-394
pubmed: 30732549
Nat Rev Immunol. 2013 Mar;13(3):190-8
pubmed: 23391992

Auteurs

Johannes Boltze (J)

School of Life Sciences, University of Warwick, Coventry, UK.

Nadine Didwischus (N)

School of Life Sciences, University of Warwick, Coventry, UK.

Martha Merrow (M)

Faculty of Medicine, Institute of Medical Psychology, LMU Munich, Munich, Germany.

Robert Dallmann (R)

Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.

Nikolaus Plesnila (N)

Institute for Stroke and Dementia Research (ISD), Munich University Hospital and Faculty of Medicine, LMU Munich, Munich, Germany.
Munich Cluster of Systems Neurology (Synergy), Munich, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Circadian effects on stroke outcome - Did we...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Circadian effects on stroke outcome - Did we...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Horloges biologiques › Horloges circadiennes › Circadian effects on stroke outcome - Did we...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Rythme circadien › Circadian effects on stroke outcome - Did we...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Circadian effects on stroke outcome - Did we...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Circadian effects on stroke outcome - Did we...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neuroprotection › Circadian effects on stroke outcome - Did we...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Circadian effects on stroke outcome - Did we...