Obesity-induced cognitive impairment in older adults: a microvascular perspective.
aging
endothelial dysfunction
metabolic syndrome
neurovascular coupling
senescence
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
pubmed:
19
12
2020
medline:
23
3
2021
entrez:
18
12
2020
Statut:
ppublish
Résumé
Over two-thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in the elderly. In this review, the pathophysiological roles of microvascular mechanisms, including impaired endothelial function and neurovascular coupling responses, microvascular rarefaction, and blood-brain barrier disruption in the genesis of cognitive impairment in geriatric obesity are considered. The potential contribution of adipose-derived factors and fundamental cellular and molecular mechanisms of senescence to exacerbated obesity-induced cerebromicrovascular impairment and cognitive decline in aging are discussed.
Identifiants
pubmed: 33337961
doi: 10.1152/ajpheart.00736.2020
pmc: PMC8091942
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
H740-H761Subventions
Organisme : NIA NIH HHS
ID : R01 AG047879
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103447
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055395
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100782
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS056218
Pays : United States
Organisme : HHS | NIH | National Institute on Aging (U.S. National Institute on Aging)
ID : 1R01AG068295-01
Organisme : NIA NIH HHS
ID : R01 AG038747
Pays : United States
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