First report of a blaNDM-resistant gene in a Klebsiella aerogenes clinical isolate from Brazil.
Journal
Revista da Sociedade Brasileira de Medicina Tropical
ISSN: 1678-9849
Titre abrégé: Rev Soc Bras Med Trop
Pays: Brazil
ID NLM: 7507456
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
05
2020
accepted:
02
09
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
23
12
2020
Statut:
epublish
Résumé
Carbapenemase-resistant enterobacteria that produce the bla NDM gene are found worldwide. However, this is the first report of blaNDM in Klebsiella aerogenes in Brazil. The identification of bacterial species was performed using anautomated system and confirmed by biochemical tests, 16S rRNA gene sequencing, and detection of resistance genes. The clinical isolate showed minimum inhibitory concentration resistance to meropenem and polymyxin B at 8mg/L and 4mg/L, respectively. Only the blaNDM gene was detected. The current report of the blaNDM gene in isolated MDR enterobacteria indicates that this gene can spread silently in a hospital setting.
Identifiants
pubmed: 33338110
pii: S0037-86822021000100610
doi: 10.1590/0037-8682-0262-2020
pmc: PMC7747820
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
RNA, Ribosomal, 16S
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e02622020Références
J Med Microbiol. 2016 Nov;65(11):1253-1259
pubmed: 27667823
Antimicrob Agents Chemother. 2002 Aug;46(8):2720-2
pubmed: 12121966
J Antimicrob Chemother. 2013 Dec;68(12):2956-7
pubmed: 23869051
Front Microbiol. 2018 Mar 07;9:407
pubmed: 29563908
Indian J Med Res. 2017 Jul;146(Supplement):S38-S45
pubmed: 29205194
Int J Infect Dis. 2014 Aug;25:79-81
pubmed: 24857802
J Glob Antimicrob Resist. 2020 Jun;21:255-261
pubmed: 31505299
Front Microbiol. 2018 Mar 29;9:571
pubmed: 29651277
Microb Drug Resist. 2019 Apr;25(3):394-399
pubmed: 30676240
J Clin Lab Anal. 2017 Mar;31(2):
pubmed: 27565452
Microb Drug Resist. 2020 Mar;26(3):284-289
pubmed: 31397624
J Antimicrob Chemother. 2019 Dec 1;74(12):3489-3496
pubmed: 31504589
BMC Microbiol. 2017 Apr 27;17(1):101
pubmed: 28449650
Microb Drug Resist. 2018 Nov;24(9):1361-1367
pubmed: 29596032