The role of miRNAs in colorectal cancer progression and chemoradiotherapy.
Biomarkers
Cancer therapy
Chemoradiotherapy
Colorectal cancer
microRNA
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
04
10
2020
revised:
17
11
2020
accepted:
02
12
2020
pubmed:
19
12
2020
medline:
2
7
2021
entrez:
18
12
2020
Statut:
ppublish
Résumé
Colorectal cancer (CRC) is known as the third most common cancer as well as the fourth most deadly cancer worldwide. CRC accounts for approximately 10 % of all new cancer cases globally, remaining the second most frequent cause of cancer-related deaths. MicroRNAs (miRNAs) are a class of small noncoding RNAs that can affect a variety of cellular and molecular targets. Depending on the cell environment in which the information is expressed, miRNAs can serve as a CRC suppressor or promoter and play essential roles in several biological processes. In this review, we summarized the relationship between miRNAs and proliferation, metastasis, angiogenesis, autophagy, apoptosis, and the chemoradiotherapy of CRC, revealing that relevant miRNAs could serve as potential targets for CRC therapy.
Identifiants
pubmed: 33338745
pii: S0753-3322(20)31292-0
doi: 10.1016/j.biopha.2020.111099
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111099Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.