Biomaterials to enhance antigen-specific T cell expansion for cancer immunotherapy.
Artificial antigen-presenting cells
Cancer immunotherapy
Immunoengineering
Particles
Scaffolds
T cell
Journal
Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
15
09
2020
revised:
22
11
2020
accepted:
26
11
2020
pubmed:
19
12
2020
medline:
25
5
2021
entrez:
18
12
2020
Statut:
ppublish
Résumé
T cells are often referred to as the 'guided missiles' of our immune system because of their capacity to traffic to and accumulate at sites of infection or disease, destroy infected or mutated cells with high specificity and sensitivity, initiate systemic immune responses, sterilize infections, and produce long-lasting memory. As a result, they are a common target for a range of cancer immunotherapies. However, the myriad of challenges of expanding large numbers of T cells specific to each patient's unique tumor antigens has led researchers to develop alternative, more scalable approaches. Biomaterial platforms for expansion of antigen-specific T cells offer a path forward towards broadscale translation of personalized immunotherapies by providing "off-the-shelf", yet modular approaches to customize the phenotype, function, and specificity of T cell responses. In this review, we discuss design considerations and progress made in the development of ex vivo and in vivo technologies for activating antigen-specific T cells, including artificial antigen presenting cells, T cell stimulating scaffolds, biomaterials-based vaccines, and artificial lymphoid organs. Ultimate translation of these platforms as a part of cancer immunotherapy regimens hinges on an in-depth understanding of T cell biology and cell-material interactions.
Identifiants
pubmed: 33338931
pii: S0142-9612(20)30830-9
doi: 10.1016/j.biomaterials.2020.120584
pmc: PMC7856270
mid: NIHMS1654339
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
120584Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB028239
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB029341
Pays : United States
Organisme : NCI NIH HHS
ID : R33 CA229042
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007057
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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