Diphenyl diselenide and cidofovir present anti-viral activity against Bovine Alphaherpesvirus 2 in vitro and in a sheep model.
Animals
Antiviral Agents
/ pharmacology
Benzene Derivatives
/ pharmacology
Cidofovir
/ pharmacology
Female
Herpes Simplex
/ drug therapy
Herpesvirus 2, Bovine
/ drug effects
Mammary Glands, Animal
/ immunology
Organoselenium Compounds
/ pharmacology
Sheep
Sheep Diseases
/ drug therapy
Virus Shedding
/ drug effects
Anti-virals
Bovine herpesvirus 2
Herpetic mammilitis
Therapy
Journal
Research in veterinary science
ISSN: 1532-2661
Titre abrégé: Res Vet Sci
Pays: England
ID NLM: 0401300
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
25
07
2020
revised:
27
11
2020
accepted:
29
11
2020
pubmed:
19
12
2020
medline:
23
3
2021
entrez:
18
12
2020
Statut:
ppublish
Résumé
Bovine alphaherpesvirus 2 (BoHV-2) - the agent of bovine herpetic mamillitis (BHM) - is related to Human alphaherpesviruses 1 and 2 (HHV-1, HHV-2) and, as such, has been proposed as a model for vaccine and drug testing. We herein investigated the anti-viral activity in vitro against BoHV-2 of three anti-herpetic drugs: Cidofovir (CDV), Fanciclovir (FAM), Foscarnet (PFA), and diphenyl disselenide (Ph
Identifiants
pubmed: 33338952
pii: S0034-5288(20)31098-5
doi: 10.1016/j.rvsc.2020.11.023
pii:
doi:
Substances chimiques
Antiviral Agents
0
Benzene Derivatives
0
Organoselenium Compounds
0
diphenyldiselenide
1666-13-3
Cidofovir
JIL713Q00N
Types de publication
Journal Article
Randomized Controlled Trial, Veterinary
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-85Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.