Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer.
cancer epigenetics
cancer metabolism
cell differentiation in cancer
mitochondrial metabolism
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
16 Dec 2020
16 Dec 2020
Historique:
received:
20
10
2020
revised:
07
12
2020
accepted:
11
12
2020
entrez:
19
12
2020
pubmed:
20
12
2020
medline:
20
12
2020
Statut:
epublish
Résumé
Metabolic reprogramming is a hallmark of cancer, with consistent rewiring of glucose, glutamine, and mitochondrial metabolism. While these metabolic alterations are adequate to meet the metabolic needs of cell growth and proliferation, the changes in critical metabolites have also consequences for the regulation of the cell differentiation state. Cancer evolution is characterized by progression towards a poorly differentiated, stem-like phenotype, and epigenetic modulation of the chromatin structure is an important prerequisite for the maintenance of an undifferentiated state by repression of lineage-specific genes. Epigenetic modifiers depend on intermediates of cellular metabolism both as substrates and as co-factors. Therefore, the metabolic reprogramming that occurs in cancer likely plays an important role in the process of the de-differentiation characteristic of the neoplastic process. Here, we review the epigenetic consequences of metabolic reprogramming in cancer, with particular focus on the role of mitochondrial intermediates and hypoxia in the regulation of cellular de-differentiation. We also discuss therapeutic implications.
Identifiants
pubmed: 33339101
pii: cancers12123788
doi: 10.3390/cancers12123788
pmc: PMC7765496
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : American Cancer Society
ID : RSG-17-003-01-CCE
Organisme : Tobacco-Related Disease Research Program
ID : 2016TRDRP0IR00000143977
Organisme : NCI NIH HHS
ID : R01 CA237401
Pays : United States
Organisme : NIH HHS
ID : R01CA237401-01A1
Pays : United States
Organisme : American Italian Cancer Foundation
ID : Fellowship
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