The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia.
candidate genes
developmental dyslexia
endophenotypes
mediation
multisensory temporal processing
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
16 Dec 2020
16 Dec 2020
Historique:
received:
13
10
2020
revised:
04
12
2020
accepted:
11
12
2020
entrez:
19
12
2020
pubmed:
20
12
2020
medline:
20
12
2020
Statut:
epublish
Résumé
Although substantial heritability has been reported and candidate genes have been identified, we are far from understanding the etiopathogenetic pathways underlying developmental dyslexia (DD). Reading-related endophenotypes (EPs) have been established. Until now it was unknown whether they mediated the pathway from gene to reading (dis)ability. Thus, in a sample of 223 siblings from nuclear families with DD and 79 unrelated typical readers, we tested four EPs (i.e., rapid auditory processing, rapid automatized naming, multisensory nonspatial attention and visual motion processing) and 20 markers spanning five DD-candidate genes (i.e.,
Identifiants
pubmed: 33339203
pii: brainsci10120993
doi: 10.3390/brainsci10120993
pmc: PMC7765588
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Italian Ministry of Health
ID : RC2019
Organisme : Italian Ministry of Health
ID : RC2020
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