Multiple Micronutrients, Lutein, and Docosahexaenoic Acid Supplementation during Lactation: A Randomized Controlled Trial.
Adult
Breast Feeding
Dietary Supplements
Docosahexaenoic Acids
/ administration & dosage
Double-Blind Method
Eicosapentaenoic Acid
/ analysis
Female
Germany
Homocysteine
/ analysis
Humans
Infant
Lactation
/ blood
Lutein
/ administration & dosage
Maternal Nutritional Physiological Phenomena
Micronutrients
/ administration & dosage
Milk, Human
/ chemistry
Vitamin B 12
/ analysis
Vitamin D
/ analogs & derivatives
beta Carotene
/ analysis
docosahexaenoic acid
lactation
lutein
maternal biomarkers
micronutrients
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
16 Dec 2020
16 Dec 2020
Historique:
received:
20
11
2020
revised:
10
12
2020
accepted:
14
12
2020
entrez:
19
12
2020
pubmed:
20
12
2020
medline:
22
4
2021
Statut:
epublish
Résumé
Breastfed infants require an adequate supply of critical nutrients for growth, tissue functions, and health. Recommended intakes for several nutrients are considerably higher in lactating than non-lactating women but are not always met with habitual diets. We report a randomized, double-blind clinical trial in 70 healthy lactating women in Germany evaluating the effects of supplementation with multiple micronutrients, lutein, and docosahexaenoic acid (DHA) compared to placebo on maternal nutrient status and milk composition. The primary endpoint was the effect on the change of human milk DHA content (as a proportion of total milk fatty acids) during 12 weeks of supplementation. Maternal blood and milk biomarkers were measured as secondary endpoints. Supplementation increased maternal milk DHA by 30% compared to a decline in the placebo group. Supplementation also increased maternal blood DHA (17%), eicosapentaenoic acid (4%), 25-OH-vitamin D (24%), vitamin B12 (12%), lutein (4%), and beta carotene (49%), while homocysteine decreased. No significant difference in the number of adverse events was observed between supplementation and placebo groups. In conclusion, multi-micronutrient supplementation was safe and increased maternal blood and milk concentrations of selected nutrients in healthy women.
Identifiants
pubmed: 33339438
pii: nu12123849
doi: 10.3390/nu12123849
pmc: PMC7765837
pii:
doi:
Substances chimiques
Micronutrients
0
beta Carotene
01YAE03M7J
Homocysteine
0LVT1QZ0BA
Vitamin D
1406-16-2
Docosahexaenoic Acids
25167-62-8
25-hydroxyvitamin D
A288AR3C9H
Eicosapentaenoic Acid
AAN7QOV9EA
Vitamin B 12
P6YC3EG204
Lutein
X72A60C9MT
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
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