Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.

Biological Specimen Banks Cardiovascular Diseases / blood Gene Silencing Gene Targeting Genome, Human Genome-Wide Association Study Humans Lipids / blood Liver / metabolism Loss of Function Mutation / genetics Molecular Targeted Therapy Phenomics Receptors, LDL / genetics United Kingdom

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
18 12 2020
Historique:
received: 21 01 2020
accepted: 17 09 2020
entrez: 19 12 2020
pubmed: 20 12 2020
medline: 16 1 2021
Statut: epublish

Résumé

Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide analyses of participants in the HUNT Study in Norway (n = 69,479) to search for protein-altering variants with beneficial impact on quantitative blood traits related to cardiovascular disease, but without detrimental impact on liver function. We identify 76 (11 previously unreported) presumed causal protein-altering variants associated with one or more CVD- or liver-related blood traits. Nine of the variants are predicted to result in loss-of-function of the protein. This includes ZNF529:p.K405X, which is associated with decreased low-density-lipoprotein (LDL) cholesterol (P = 1.3 × 10

Identifiants

DOI: 10.1038/s41467-020-20086-3 PMID: 33339817 PMC: PMC7749177
pubmed: 33339817
doi: 10.1038/s41467-020-20086-3
pii: 10.1038/s41467-020-20086-3
pmc: PMC7749177
doi:

Substances chimiques

LDLR protein, human 0
Lipids 0
Receptors, LDL 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6417

Subventions

Organisme : NIA NIH HHS
ID : N01AG12109
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL109946
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139731
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135824
Pays : United States
Organisme : NIDA NIH HHS
ID : HHSN271201100005C
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK062370
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK062370
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130705
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL140203
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117626
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG000040
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL123333
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138139
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL150233
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132476
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137214
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL068878
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127564
Pays : United States

Références

Nat Biotechnol. 2013 Dec;31(12):1102-10
pubmed: 24270849
Genet Med. 2013 Jul;15(7):565-74
pubmed: 23788249
Nat Genet. 2017 Dec;49(12):1758-1766
pubmed: 29083408
JAMA. 2018 Apr 17;319(15):1566-1579
pubmed: 29677301
J Mol Cell Cardiol. 2011 Aug;51(2):244-51
pubmed: 21600901
Nat Genet. 2018 Mar;50(3):390-400
pubmed: 29403010
Nat Rev Drug Discov. 2013 Aug;12(8):581-94
pubmed: 23868113
Nat Genet. 2018 Sep;50(9):1234-1239
pubmed: 30061737
Lancet. 2010 Feb 27;375(9716):735-42
pubmed: 20167359
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
Eur Rev Med Pharmacol Sci. 2020 Jan;24(2):893-904
pubmed: 32016996
PLoS Genet. 2012;8(8):e1002793
pubmed: 22876189
PLoS Genet. 2006 Aug 25;2(8):e132
pubmed: 16934002
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Nat Genet. 2018 Nov;50(11):1514-1523
pubmed: 30275531
Int J Epidemiol. 2013 Aug;42(4):968-77
pubmed: 22879362
Nat Genet. 2020 Jun;52(6):634-639
pubmed: 32424355
J Clin Endocrinol Metab. 2006 Jun;91(6):2279-85
pubmed: 16595594
Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):e38-e81
pubmed: 30580575
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
EBioMedicine. 2019 Mar;41:62-72
pubmed: 30772307
Biochemistry. 2017 Jan 24;56(3):525-533
pubmed: 27984852
Nucleic Acids Res. 2011 Jan;39(Database issue):D712-7
pubmed: 21071422
Nucleic Acids Res. 1988 Sep 12;16(17):8361-75
pubmed: 2843815
J Bone Miner Res. 2012 Jan;27(1):93-103
pubmed: 21956185
Nat Rev Genet. 2013 Sep;14(9):661-73
pubmed: 23917628
Nat Genet. 2018 Sep;50(9):1335-1341
pubmed: 30104761
Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14270-14279
pubmed: 31235580
Respir Res. 2017 Sep 15;18(1):171
pubmed: 28915894
Nucleic Acids Res. 2010 Sep;38(16):e164
pubmed: 20601685
Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1169-77
pubmed: 12615685
Nat Genet. 2011 Oct 16;43(11):1131-8
pubmed: 22001757
Nat Genet. 2010 Apr;42(4):348-54
pubmed: 20208533
Blood. 2013 Jul 18;122(3):443-55
pubmed: 23723450
Lancet. 1994 Nov 19;344(8934):1383-9
pubmed: 7968073
Cell Metab. 2016 Aug 9;24(2):223-33
pubmed: 27508871
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
JMIR Med Inform. 2019 Nov 29;7(4):e14325
pubmed: 31553307
Nat Genet. 2015 Nov;47(11):1272-1281
pubmed: 26366554
Lancet. 2015 Jan 10;385(9963):117-71
pubmed: 25530442
J Clin Lipidol. 2017 Nov - Dec;11(6):1329-1337.e3
pubmed: 28951076
J Res Med Sci. 2010 May;15(3):150-4
pubmed: 21526074
Am J Hum Genet. 2018 Jan 4;102(1):103-115
pubmed: 29290336
Genome Biol. 2013 Apr 25;14(4):R36
pubmed: 23618408
Redox Biol. 2018 May;15:522-531
pubmed: 29413964
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379
Nat Genet. 2015 Aug;47(8):856-60
pubmed: 26121088
J Clin Invest. 1981 Oct;68(4):1012-7
pubmed: 6457059
N Engl J Med. 2009 Jun 25;360(26):2749-57
pubmed: 19553648
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1738-1747
pubmed: 29954752
N Engl J Med. 2012 Oct 4;367(14):1310-20
pubmed: 23034020
Circ Res. 2018 Mar 30;122(7):945-957
pubmed: 29467198
Nat Commun. 2016 Nov 21;7:13516
pubmed: 27869117

Auteurs

Jonas B Nielsen (JB)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA. jonas.bille.nielsen@gmail.com.
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. jonas.bille.nielsen@gmail.com.
ORCID: 0000-0002-6654-2852

Oren Rom (O)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.

Ida Surakka (I)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.

Sarah E Graham (SE)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0003-1271-2489

Wei Zhou (W)

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0001-7719-0859

Tanmoy Roychowdhury (T)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.

Lars G Fritsche (LG)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0002-2110-1690

Sarah A Gagliano Taliun (SA)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0003-1306-1868

Carlo Sidore (C)

Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
ORCID: 0000-0001-7504-7477

Yuhao Liu (Y)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.

Maiken E Gabrielsen (ME)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.

Anne Heidi Skogholt (AH)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.

Brooke Wolford (B)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0003-3153-1552

William Overton (W)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Ying Zhao (Y)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.

Jin Chen (J)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.

He Zhang (H)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0001-9198-6503

Whitney E Hornsby (WE)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.

Akua Acheampong (A)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.

Austen Grooms (A)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.

Amanda Schaefer (A)

Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.

Gregory J M Zajac (GJM)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0001-6411-9666

Luis Villacorta (L)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0001-7824-7028

Jifeng Zhang (J)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.

Ben Brumpton (B)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
ORCID: 0000-0002-3058-1059

Mari Løset (M)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
Department of Dermatology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
ORCID: 0000-0003-3736-6551

Vivek Rai (V)

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

Pia R Lundegaard (PR)

Laboratory for Molecular Cardiology, Department of Cardiology, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0002-8284-1844

Morten S Olesen (MS)

Laboratory for Molecular Cardiology, Department of Cardiology, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0001-9477-5322

Kent D Taylor (KD)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Los Angeles Biomedical Research Institute, Harbor-UCLA, Torrance, CA, USA.
ORCID: 0000-0002-2756-4370

Nicholette D Palmer (ND)

Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
ORCID: 0000-0001-8883-2511

Yii-Der Chen (YD)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Los Angeles Biomedical Research Institute, Harbor-UCLA, Torrance, CA, USA.

Seung H Choi (SH)

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Steven A Lubitz (SA)

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

Patrick T Ellinor (PT)

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0002-2067-0533

Kathleen C Barnes (KC)

Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
ORCID: 0000-0002-3030-4705

Michelle Daya (M)

Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.
ORCID: 0000-0002-9057-6593

Nicholas Rafaels (N)

Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.

Scott T Weiss (ST)

Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-7196-303X

Jessica Lasky-Su (J)

Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Russell P Tracy (RP)

Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
ORCID: 0000-0002-0080-2420

Ramachandran S Vasan (RS)

Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
Framingham Heart Study, Framingham, MA, USA.
ORCID: 0000-0001-7357-5970

L Adrienne Cupples (LA)

Framingham Heart Study, Framingham, MA, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
ORCID: 0000-0003-0273-7965

Rasika A Mathias (RA)

GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Lisa R Yanek (LR)

GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0001-7117-1075

Lewis C Becker (LC)

GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Patricia A Peyser (PA)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-9717-8459

Lawrence F Bielak (LF)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-3443-8030

Jennifer A Smith (JA)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-3575-5468

Stella Aslibekyan (S)

The University of Alabama at Birmingham, Birmingham, AL, USA.
23andMe, Inc., Sunnyvale, CA, USA.

Bertha A Hidalgo (BA)

The University of Alabama at Birmingham, Birmingham, AL, USA.

Donna K Arnett (DK)

Deans Office, College of Public Health, University of Kentucky, Lexington, KY, USA.

Marguerite R Irvin (MR)

The University of Alabama at Birmingham, Birmingham, AL, USA.

James G Wilson (JG)

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Jackson Heart Study, Jackson, MS, USA.

Solomon K Musani (SK)

Jackson Heart Study, Jackson, MS, USA.
Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Adolfo Correa (A)

Jackson Heart Study, Jackson, MS, USA.
Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
ORCID: 0000-0002-9501-600X

Stephen S Rich (SS)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
ORCID: 0000-0003-3872-7793

Xiuqing Guo (X)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Los Angeles Biomedical Research Institute, Harbor-UCLA, Torrance, CA, USA.

Jerome I Rotter (JI)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Los Angeles Biomedical Research Institute, Harbor-UCLA, Torrance, CA, USA.
ORCID: 0000-0001-7191-1723

Barbara A Konkle (BA)

BloodWorks Northwest, University of Washington, Seattle, WA, USA.

Jill M Johnsen (JM)

BloodWorks Northwest, University of Washington, Seattle, WA, USA.

Allison E Ashley-Koch (AE)

Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
ORCID: 0000-0001-5409-9155

Marilyn J Telen (MJ)

Department of Medicine, Duke University Medical Center, Durham, NC, USA.
ORCID: 0000-0003-3809-1780

Vivien A Sheehan (VA)

Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA.
ORCID: 0000-0003-2837-2255

John Blangero (J)

Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
ORCID: 0000-0001-6250-5723

Joanne E Curran (JE)

Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.

Juan M Peralta (JM)

Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
ORCID: 0000-0002-8811-5579

Courtney Montgomery (C)

Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma, OK, USA.

Wayne H-H Sheu (WH)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Ren-Hua Chung (RH)

Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.

Karen Schwander (K)

Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.

Seyed M Nouraie (SM)

University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Victor R Gordeuk (VR)

University of Illinois at Chicago, Chicago, IL, USA.

Yingze Zhang (Y)

University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Charles Kooperberg (C)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Alexander P Reiner (AP)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.

Rebecca D Jackson (RD)

Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, OH, USA.

Eugene R Bleecker (ER)

Division of Pharmacogenomics University of Arizona, Tucson, AR, USA.

Deborah A Meyers (DA)

Division of Pharmacogenomics University of Arizona, Tucson, AR, USA.

Xingnan Li (X)

Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AR, USA.
ORCID: 0000-0002-1208-8658

Sayantan Das (S)

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0001-6346-1590

Ketian Yu (K)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0001-9994-3399

Jonathon LeFaive (J)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0003-3668-6086

Albert Smith (A)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0003-1942-5845

Tom Blackwell (T)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Daniel Taliun (D)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Sebastian Zollner (S)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Lukas Forer (L)

Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AR, USA.

Sebastian Schoenherr (S)

Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

Christian Fuchsberger (C)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Institute for Biomedicine, Eurac Research, Bolzano, Italy.

Anita Pandit (A)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Matthew Zawistowski (M)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0002-3005-083X

Sachin Kheterpal (S)

Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.

Chad M Brummett (CM)

Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.

Pradeep Natarajan (P)

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-8402-7435

David Schlessinger (D)

Laboratory of Genetics, National Institute on Aging, US National Institutes of Health, Baltimore, MD, USA.

Seunggeun Lee (S)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0002-8097-3878

Hyun Min Kang (HM)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Francesco Cucca (F)

Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.
ORCID: 0000-0002-7414-1995

Oddgeir L Holmen (OL)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.

Bjørn O Åsvold (BO)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.
Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
ORCID: 0000-0003-3837-2101

Michael Boehnke (M)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0002-6442-7754

Sekar Kathiresan (S)

Harvard Medical School, Boston, MA, USA.
Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Broad Institute, Cambridge, MD, USA.
ORCID: 0000-0002-6724-032X

Goncalo R Abecasis (GR)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Regeneron Pharmaceuticals, Tarrytown, NY, USA.
ORCID: 0000-0003-1509-1825

Y Eugene Chen (YE)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA. echenum@umich.edu.
ORCID: 0000-0003-2357-7825

Cristen J Willer (CJ)

Department of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu.
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. cristen@umich.edu.
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu.
Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu.
ORCID: 0000-0001-5645-4966

Kristian Hveem (K)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. kristian.hveem@ntnu.no.
HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway. kristian.hveem@ntnu.no.
Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway. kristian.hveem@ntnu.no.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Biobanques › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Maladies cardiovasculaires › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome humain › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Lipides › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Système digestif › Foie › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation perte de fonction › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Phénomique › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Loss-of-function genomic variants highlight...
questionsmedicales.fr › Régions géographiques › Europe › Royaume-Uni › Loss-of-function genomic variants highlight...