Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients.
Journal
NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891
Informations de publication
Date de publication:
18 Dec 2020
18 Dec 2020
Historique:
received:
03
06
2020
accepted:
12
11
2020
entrez:
19
12
2020
pubmed:
20
12
2020
medline:
20
12
2020
Statut:
epublish
Résumé
Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic surgery. Survival analyses showed that the presence of a desmoplastic HGP in the liver metastases (a rim of fibrous tissue separating cancer cells from the liver parenchyma, present in 20 (56%) patients) is independently associated with favorable progression-free and overall survival when compared with the replacement HGP (cancer cells growing into the liver parenchyma, present in 16 (44%) patients).
Identifiants
pubmed: 33339824
doi: 10.1038/s41523-020-00209-1
pii: 10.1038/s41523-020-00209-1
pmc: PMC7749172
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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