Benign connective and soft-tissue neoplasms of the oral and maxillofacial region: Cross-sectional study of 1066 histopathological specimens.
connective tissue
diagnosis
neoplasms
oral pathology
soft-tissue neoplasms
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
11
11
2020
received:
27
05
2020
accepted:
08
12
2020
pubmed:
20
12
2020
medline:
1
7
2021
entrez:
19
12
2020
Statut:
ppublish
Résumé
Benign connective and soft-tissue neoplasms (CSTNs) are unusual in the head and neck region. The aim of the present study was to evaluate the demographic and clinicopathological features of these neoplasms. A cross-sectional study was conducted of cases diagnosed as benign CSTNs, with data collected from biopsy records. The chi-square test was used. A p-value <0.05 was considered indicative of statistical significance. Among the 38 119 specimens, 1066 (2.79%) were benign CSTNs: 369 fibroblastic/myofibroblastic, 250 adipocytic, 179 vascular, 130 neural, 94 osseous/cartilaginous, 19 muscular, and two fibrohistiocytic. Most patients were female (62.8%) and white-skinned (45.8%). Mean age was 42 years. The tongue (25.2%) was the most affected site for extraosseous neoplasms. This study had the largest sample of benign oral and maxillofacial CSTNs. Although these tumors have similar clinical features, the characterization and differentiation detailed here may help clinicians with regards to the correct diagnosis.
Sections du résumé
BACKGROUND
Benign connective and soft-tissue neoplasms (CSTNs) are unusual in the head and neck region. The aim of the present study was to evaluate the demographic and clinicopathological features of these neoplasms.
METHODS
A cross-sectional study was conducted of cases diagnosed as benign CSTNs, with data collected from biopsy records. The chi-square test was used. A p-value <0.05 was considered indicative of statistical significance.
RESULTS
Among the 38 119 specimens, 1066 (2.79%) were benign CSTNs: 369 fibroblastic/myofibroblastic, 250 adipocytic, 179 vascular, 130 neural, 94 osseous/cartilaginous, 19 muscular, and two fibrohistiocytic. Most patients were female (62.8%) and white-skinned (45.8%). Mean age was 42 years. The tongue (25.2%) was the most affected site for extraosseous neoplasms.
CONCLUSION
This study had the largest sample of benign oral and maxillofacial CSTNs. Although these tumors have similar clinical features, the characterization and differentiation detailed here may help clinicians with regards to the correct diagnosis.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1202-1212Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Weiss E. Tumours of the soft (mesenchymal) tissues. Bull World Health Organ. 1974;50(1-2):101-110.
Gardner DL. Diseases of connective tissue: a consensus. J Clin Pathol Suppl (R Coll Pathol). 1978;12:223-238.
Ruoslahti E. How cancer spreads. Sci Am. 1996;275(3):72-77.
El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, eds. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: IARC; 2017:347.
Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, eds. WHO Classification of Tumours of Soft Tissue and Bone. 4th ed. Lyon: IARC Press; 2013:468.
Alotaiby FM, Fitzpatrick S, Upadhyaya J, Islam MN, Cohen D, Bhattacharyya I. Demographic, clinical and histopathological features of oral neural neoplasms: a retrospective study. Head Neck Pathol. 2019;13(2):208-214.
Boffano P, Roccia F, Campisi P, Gallesio C. Review of 43 osteomas of the craniomaxillofacial region. J Oral Maxillofac Surg. 2012;70(5):1093-1095.
Jones AC, Freedman PD, Kerpel SM. Oral myofibromas: a report of 13 cases and review of the literature. J Oral Maxillofac Surg. 1994;52(8):870-875.
Brasileiro BF, Martins-Filho PR, Piva MR, da Silva LC, Nonaka CF, Miguel MC. Myofibroma of the oral cavity. A rare spindle cell neoplasm. Med Oral Patol Oral Cir Bucal. 2010;15(4):596-600.
Polak M, Polak G, Brocheriou C, Vigneul J. Solitary neurofibroma of the mandible: case report and review of the literature. J Oral Maxillofac Surg. 1989;47(1):65-68.
Kaplan I, Nicolaou Z, Hatuel D, Calderon S. Solitary central osteoma of the jaws: a diagnostic dilemma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(3):22-29.
Boffano P, Bosco GF, Gerbino G. The surgical management of oral and maxillofacial manifestations of Gardner syndrome. J Oral Maxillofac Surg. 2010;68(10):2549-2554.
Oliveira MR, Rodrigues WC, Gabrielli MF, Gabrielli MA, Onofre MA, Filho VA. Gardner syndrome with unusual maxillofacial manifestation. J Craniofac Surg. 2016;27(5):1253-1255.
Wijn MA, Keller JJ, Giardiello FM, Brand HS. Oral and maxillofacial manifestations of familial adenomatous polyposis. Oral Dis. 2007;13(4):360-365.
Yu D, Benjamin NG, Zhu H, Liu J, Lin Y. Bone and dental abnormalities as first signs of familial Gardner's syndrome in a Chinese family: a literature review and a case report. Med Sci. 2018;34:20-25.
Cristofaro MG, Giudice A, Amantea M, Riccelli U, Giudice M. Gardner's syndrome: a clinical and genetic study of a family. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(3):1-6.
Ramaglia L, Morgese F, Filippella M, Colao A. Oral and maxillofacial manifestations of Gardner's syndrome associated with growth hormone deficiency: case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103(6):30-34.
da Silva LAB, Monroy EAC, Serpa MS, de Souza LB. Oral benign neoplasms: a retrospective study of 790 patients over a 14-year period. Acta Otorrinolaringol Esp. 2019;70(3):158-164.
Torres-Domingo S, Bagan JV, Jiménez Y, et al. Benign tumors of the oral mucosa: a study of 300 patients. Med Oral Patol Oral Cir Bucal. 2008;13(3):161-166.
Furlong MA, Fanburg-Smith JC, Childers EL. Lipoma of the oral and maxillofacial region: site and subclassification of 125 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98(4):441-450.
do Nascimento GJ, de Albuquerque Pires Rocha D, Galvão HC, de Lisboa Lopes Costa A, de Souza LB. A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study. Clin Oral Investig. 2011;15(3):329-335.
Kaur G, Gondal R. Oral leiomyoma. J Oral Maxillofac Pathol. 2011;15(3):361-362.
de Trey LA, Schmid S, Huber GF. Multifocal adult rhabdomyoma of the head and neck manifestation in 7 locations and review of the literature. Case Rep Otolaryngol. 2013;2013:758416.
Piattelli A, Fioroni M, Rubini C. Spindle cell lipoma of the oral cavity: report of case. J Oral Maxillofac Surg. 1999;57(5):624-625.
Shemen L, Spiro R, Tuazon R. Multifocal adult rhabdomyomas of the head and neck. Head Neck. 1992;14(5):395-400.
Houston GD. The giant cell fibroma: a review of 464 cases. Oral Surg Oral Med Oral Pathol. 1982;53(6):582-587.
Magnusson BC, Rasmusson LG. The giant cell fibroma a review of 103 cases with immunohistochemical findings. Acta Odontol Scand. 1995;53(5):293-296.
Pereira de Oliveira DHI, da Silveira É, de Souza LB, et al. Myofibroblastic lesions in the oral cavity: Immunohistochemical and ultrastructural analysis. Oral Dis. 2019;25(1):174-181.
Corrêa PH, Nunes LC, Johann AC, Aguiar MC, Gomez RS, Mesquita RA. Prevalence of oral hemangioma, vascular malformation and varix in a Brazilian population. Braz Oral Res. 2007;21(1):40-45.
Jones AC, Prihoda TJ, Kacher JE, Odingo NA, Freedman PD. Osteoblastoma of the maxilla and mandible: a report of 24 cases, review of the literature, and discussion of its relationship to osteoid osteoma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102(5):639-650.
Larrea-Oyarbide N, Valmaseda-Castellón E, Berini-Aytés L, Gay-Escoda C. Osteomas of the craniofacial region. Review of 106 cases. J Oral Pathol Med. 2008;37(1):38-42.
Weathers DR, Callihan MD. Giant cell fibroma. Oral Surg Oral Med Oral Pathol. 1974;37(3):374-384.
Kuo RC, Wang YP, Chen HM, Sun A, Liu BY, Kuo YS. Clinicopathological study of oral giant cell fibromas. J Formos Med Assoc. 2009;108(9):725-729.
Sabarinath B, Sivaramakrishnan M, Sivapathasundharam B. Giant cell fibroma: a clinicopathological study. J Oral Maxillofac Pathol. 2012;16(3):359-362.
Schmidt MJ, Tschoeke A, Noronha L, et al. Histochemical analysis of collagen fibers in giant cell fibroma and inflammatory fibrous hyperplasia. Acta Histochem. 2016;118(5):451-455.
Datar UV, Mohan BC, Hallikerimath S, Angadi P, Kale A, Mane D. Clinicopathologic study of a series of giant cell fibroma using picrosirius red polarizing microscopy technique. Arch Iran Med. 2014;17(11):746-749.
Perez-Sayáns M, Blanco-Carrión A, Oliveira-Alves MG, et al. Multicentre retrospective study of 97 cases of intraoral lipoma. J Oral Pathol Med. 2019;48(6):499-504.
Juliasse LE, Nonaka CF, Pinto LP, Freitas Rde A, Miguel MC. Lipomas of the oral cavity: clinical and histopathologic study of 41 cases in a Brazilian population. Eur Arch Otorhinolaryngol. 2010;267(3):459-465.
Tamiolakis P, Chrysomali E, Sklavounou-Andrikopoulou A, Nikitakis NG. Oral neural tumors: clinicopathologic analysis of 157 cases and review of the literature. J Clin Exp Dent. 2019;11(8):721-731.
de Pontes Santos HB, de Morais EF, Moreira DG, Marinho LCN, Galvão HC, de Almeida Freitas R. Neurofibromas of the oral and maxillofacial complex: a 48-year retrospective study. J Cutan Pathol. 2020;47(3):202-206.
Ellis GL, Abrams AM, Melrose RJ. Intraosseous benign neural sheath neoplasms of the jaws: report of seven new cases and review of the literature. Oral Surg Oral Med Oral Pathol. 1977;44(5):731-743.
Larsson A, Praetorius F, Hjörting-Hansen E. Intraosseous neurofibroma of the jaws. Int J Oral Surg. 1978;7(5):494-499.
Apostolidis C, Anterriotis D, Rapidis AD, Angelopoulos AP. Solitary intraosseous neurofibroma of the inferior alveolar nerve: report of a case. J Oral Maxillofac Surg. 2001;59(2):232-235.
Bongiorno MR, Pistone G, Aricò M. Manifestations of the tongue in Neurofibromatosis type 1. Oral Dis. 2006;12(2):125-129.
Foss RD, Ellis GL. Myofibromas and myofibromatosis of the oral region: a clinicopathologic analysis of 79 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(1):57-65.
Demo PG, Savoini M, Marchetti M, Maletta F, Zavattero E, Ramieri G. Surgical management of myofibroma of the gengiva. J Craniofac Surg. 2016;27(7):646-648.
Vered M, Allon I, Buchner A, Dayan D. Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity. II. Myofibroma and myofibromatosis of the oral soft tissues. J Oral Pathol Med. 2007;36(5):304-314.
Sugatani T, Inui M, Tagawa T, Seki Y, Mori A, Yoneda J. Myofibroma of the mandible: clinicopathologic study and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;80(3):303-309.
Speight PM, Dayan D, Fletcher CD. Adult and infantile myofibromatosis: a report of three cases affecting the oral cavity. J Oral Pathol Med. 1991;20(8):380-384.
Azevedo LH, Strefezza C. Hemangioma and lymphangioma. In: Freitas PM, Simões A, eds. Lasers in Dentistry: Guide for Clinical Practice. Hoboken, NJ: Wiley-Blackwell; 2015:248-252.
Rahsepar B, Nikgoo A, Fatemitabar SA. Osteoid osteoma of subcondylar region: case report and review of the literature. J Oral Maxillofac Surg. 2009;67(4):888-893.
Heitz C, Vogt BF, Bergoli RD, Hirsch WD, de Souza CE, Silva DN. Chondroma in temporomandibular region-case report and therapeutic considerations. Oral Maxillofac Surg. 2012;16(1):75-78.
Dell'Aversana Orabona G, Salzano G, Iaconetta G, et al. Facial osteomas: fourteen cases and a review of literature. Eur Rev Med Pharmacol Sci. 2015;19(10):1796-1802.
Sayan NB, Uçok C, Karasu HA, Günhan Ö. Peripheral osteoma of the oral and maxillofacial region: a study of 35 new cases. J Oral Maxillofac Surg. 2002;60(11):1299-1301.
Roychoudhury A, Bhatt K, Yadav R, Bhutia O, Roychoudhury S. Review of osteochondroma of mandibular condyle and report of a case series. J Oral Maxillofac Surg. 2011;69(11):2815-2823.
Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159-174.