Prorenin periconceptionally and in pregnancy: Does it have a physiological role?
Corpus luteum
Luteal phase
Preeclampsia
Pregnancy
Prorenin
Renin-angiotensin-aldosterone system
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
27
05
2020
revised:
24
11
2020
accepted:
06
12
2020
pubmed:
20
12
2020
medline:
13
8
2021
entrez:
19
12
2020
Statut:
ppublish
Résumé
Pregnancy demands major cardiovascular, renal and endocrine changes to provide an adequate blood supply for the growing fetus. The renin-angiotensin-aldosterone system plays a key role in this adaptation process. One of its components, prorenin, is released in significant amounts from the ovary and uteroplacental unit. This review describes the sources of prorenin in the periconception period and in pregnancy, including its modulation by in-vitro fertilization protocols, and discusses its potential effects, among others focusing on preeclampsia. It ends with discussing the long-term consequences, even in later life, of inappropriate renin-angiotensin-aldosterone system activity in pregnancy and offers directions for future research. Ultimately, a full understanding of the role of prorenin periconceptionally and during pregnancy will help to develop tools to diagnose and/or prevent reproductive complications.
Identifiants
pubmed: 33340569
pii: S0303-7207(20)30420-2
doi: 10.1016/j.mce.2020.111118
pii:
doi:
Substances chimiques
Renin
EC 3.4.23.15
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111118Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.