Spontaneous portosystemic shunts in cirrhosis: Detection, implications, and clinical associations.
Cirrhosis
Hepatic encephalopathy
Portal hypertension
Portosystemic shunt
Journal
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
05
07
2020
revised:
31
10
2020
accepted:
18
11
2020
pubmed:
21
12
2020
medline:
8
2
2022
entrez:
20
12
2020
Statut:
ppublish
Résumé
Spontaneous portosystemic shunts (SPSS) are common in cirrhosis. Their characterization and clinical implications remain unclear. To devise a system of assessment of these shunts, and assess their clinical implications METHODS: We retrospectively studied patients with cirrhosis who underwent imaging in a liver transplant program. A novel index was computed to assess total SPSS -the diameter of a circle having an area equivalent to the sum of the areas of all the existing shunts. This 'SPSS equivalent diameter' was compared with the clinical variables. Among 127 patients, 70% (CI The SPSS equivalent diameter, a comprehensive assessment of portosystemic shunting, was associated with severity of liver disease, hyperammonemia, and cognitive dysfunction. The diameter of the inferior vena cava was a good predictor of SPSS.
Sections du résumé
BACKGROUND
BACKGROUND
Spontaneous portosystemic shunts (SPSS) are common in cirrhosis. Their characterization and clinical implications remain unclear.
AIMS
OBJECTIVE
To devise a system of assessment of these shunts, and assess their clinical implications METHODS: We retrospectively studied patients with cirrhosis who underwent imaging in a liver transplant program. A novel index was computed to assess total SPSS -the diameter of a circle having an area equivalent to the sum of the areas of all the existing shunts. This 'SPSS equivalent diameter' was compared with the clinical variables.
RESULTS
RESULTS
Among 127 patients, 70% (CI
CONCLUSIONS
CONCLUSIONS
The SPSS equivalent diameter, a comprehensive assessment of portosystemic shunting, was associated with severity of liver disease, hyperammonemia, and cognitive dysfunction. The diameter of the inferior vena cava was a good predictor of SPSS.
Identifiants
pubmed: 33341422
pii: S1590-8658(20)31041-0
doi: 10.1016/j.dld.2020.11.020
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1468-1475Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest In the name of all the authors, I undersigned Piero Amodio, declares that no Author has any conflict of interest with the paper.