A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA).

Adult Aging / genetics Alzheimer Disease / diagnostic imaging Australia Biomarkers Brain / diagnostic imaging Cognitive Dysfunction / diagnostic imaging Cohort Studies Disease Progression Humans Prospective Studies
Alzheimer’s disease At risk cohort Genetic risk prediction Neuroimaging Neuropsychology Protocol

Journal

NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070

Informations de publication

Date de publication:
2021
Historique:
received: 24 06 2020
revised: 11 11 2020
accepted: 04 12 2020
pubmed: 21 12 2020
medline: 29 6 2021
entrez: 20 12 2020
Statut: ppublish

Résumé

This prospective cohort study, "Prospective Imaging Study of Ageing: Genes, Brain and Behaviour" (PISA) seeks to characterise the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). In particular, we are recruiting midlife and older Australians with high and low genetic risk of dementia to discover biological markers of early neuropathology, identify modifiable risk factors, and establish the very earliest phenotypic and neuronal signs of disease onset. PISA utilises genetic prediction to recruit and enrich a prospective cohort and follow them longitudinally. Online surveys and cognitive testing are used to characterise an Australia-wide sample currently totalling over 3800 participants. Participants from a defined at-risk cohort and positive controls (clinical cohort of patients with mild cognitive impairment or early AD) are invited for onsite visits for detailed functional, structural and molecular neuroimaging, lifestyle monitoring, detailed neurocognitive testing, plus blood sample donation. This paper describes recruitment of the PISA cohort, study methodology and baseline demographics.

Identifiants

DOI: 10.1016/j.nicl.2020.102527 PMID: 33341723 PMC: PMC7750170
pubmed: 33341723
pii: S2213-1582(20)30364-8
doi: 10.1016/j.nicl.2020.102527
pmc: PMC7750170
pii:
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102527

Subventions

Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG032984
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG016976
Pays : United States
Organisme : NIA NIH HHS
ID : N01AG12100
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG033193
Pays : United States
Organisme : Wellcome Trust
ID : 082604/2/07/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : Medical Research Council
ID : 503480
Pays : United Kingdom

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Michelle K Lupton (MK)

QIMR Berghofer Medical Research Institute, Brisbane, Australia. Electronic address: Michelle.Lupton@qimrberghofer.edu.au.

Gail A Robinson (GA)

School of Psychology, The University of Queensland, St. Lucia, Brisbane, Australia; Queensland Brain Institute, The University of Queensland, St. Lucia, Brisbane, Australia.

Robert J Adam (RJ)

QIMR Berghofer Medical Research Institute, Brisbane, Australia; Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Australia; Royal Brisbane and Women's Hospital Mental Health Services, University of Queensland, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia.

Stephen Rose (S)

CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia.

Gerard J Byrne (GJ)

Royal Brisbane and Women's Hospital Mental Health Services, University of Queensland, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia.

Olivier Salvado (O)

CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia.

Nancy A Pachana (NA)

School of Psychology, The University of Queensland, St. Lucia, Brisbane, Australia.

Osvaldo P Almeida (OP)

Medical School, University of Western Australia, Perth, Australia; WA Centre for Health and Ageing of the University of Western Australia, Australia.

Kerrie McAloney (K)

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Scott D Gordon (SD)

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Parnesh Raniga (P)

CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia.

Amir Fazlollahi (A)

CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia.

Ying Xia (Y)

CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia.

Amelia Ceslis (A)

School of Psychology, The University of Queensland, St. Lucia, Brisbane, Australia.

Saurabh Sonkusare (S)

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Qing Zhang (Q)

CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia.

Mahnoosh Kholghi (M)

CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia.

Mohan Karunanithi (M)

CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia.

Philip E Mosley (PE)

QIMR Berghofer Medical Research Institute, Brisbane, Australia; Queensland Brain Institute, The University of Queensland, St. Lucia, Brisbane, Australia; Neurosciences Queensland, Brisbane, Queensland, Australia.

Jinglei Lv (J)

Sydney Imaging & School of Biomedical Engineering, The University of Sydney, Sydney, Australia.

Léonie Borne (L)

The University of Newcastle, Newcastle, Australia.

Jessica Adsett (J)

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Natalie Garden (N)

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Jurgen Fripp (J)

CSIRO Health and Biosecurity, Australian E-Health Research Centre, Brisbane, Australia.

Nicholas G Martin (NG)

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Christine C Guo (CC)

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Michael Breakspear (M)

QIMR Berghofer Medical Research Institute, Brisbane, Australia; The University of Newcastle, Newcastle, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › A prospective cohort study of prodromal...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › A prospective cohort study of prodromal...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › A prospective cohort study of prodromal...
questionsmedicales.fr › Régions géographiques › Océanie › Australasie › Australie › A prospective cohort study of prodromal...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › A prospective cohort study of prodromal...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › A prospective cohort study of prodromal...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › A prospective cohort study of prodromal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › A prospective cohort study of prodromal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › A prospective cohort study of prodromal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A prospective cohort study of prodromal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › A prospective cohort study of prodromal...