Structural and Functional Characterization of a Na

Animals Calcium / metabolism Calcium Signaling Cell Line Female Humans Kinetics Male Mice, Inbred C57BL Microscopy, Electron, Scanning Mitochondria, Heart / metabolism Mitochondrial Proteins / genetics Myocytes, Cardiac / metabolism NAV1.5 Voltage-Gated Sodium Channel / genetics Single Molecule Imaging Sodium-Calcium Exchanger / genetics Superoxides / metabolism
cardiac myocytes mitochondria sodium channels

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
05 02 2021
Historique:
pubmed: 22 12 2020
medline: 27 7 2021
entrez: 21 12 2020
Statut: ppublish

Résumé

The cardiac sodium channel Na To characterize a subcellular domain formed by sodium channel clusters in the crest region of the myocytes and the subjacent subsarcolemmal mitochondria. Through a combination of imaging approaches including super-resolution microscopy and electron microscopy we identified, in adult cardiac myocytes, a Na We describe an anatomic hub (a couplon) formed by sodium channel clusters and subjacent subsarcolemmal mitochondria. Preferential localization of NCLX to this domain allows for functional coupling where the extrusion of Ca

Identifiants

DOI: 10.1161/CIRCRESAHA.120.318239 PMID: 33342222 PMC: PMC7864872
pubmed: 33342222
doi: 10.1161/CIRCRESAHA.120.318239
pmc: PMC7864872
mid: NIHMS1657190
doi:

Substances chimiques

Mitochondrial Proteins 0
NAV1.5 Voltage-Gated Sodium Channel 0
SCN5A protein, human 0
SLC8B1 protein, human 0
Scn5a protein, mouse 0
Slc8b1protein, mouse 0
Sodium-Calcium Exchanger 0
Superoxides 11062-77-4
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

419-432

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL148609
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL145911
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134328
Pays : United States
Organisme : NIH HHS
ID : S10 OD019974
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016087
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136179
Pays : United States

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Auteurs

Marta Pérez-Hernández (M)

Leon H Charney Division of Cardiology (M.P.-H., A.L.-M., J.-C.K., E.A.-P., S.V., M.Z., M.D.), NYU Grossman School of Medicine, NY.

Alejandra Leo-Macias (A)

Leon H Charney Division of Cardiology (M.P.-H., A.L.-M., J.-C.K., E.A.-P., S.V., M.Z., M.D.), NYU Grossman School of Medicine, NY.

Sarah Keegan (S)

Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology (S.K., D.F., E.R.), NYU Grossman School of Medicine, NY.

Mariam Jouni (M)

Department of Pharmacology, Northwestern University Feinberg School of Medicine. Chicago, IL (M.J., P.B.).

Joon-Chul Kim (JC)

Leon H Charney Division of Cardiology (M.P.-H., A.L.-M., J.-C.K., E.A.-P., S.V., M.Z., M.D.), NYU Grossman School of Medicine, NY.

Esperanza Agullo-Pascual (E)

Leon H Charney Division of Cardiology (M.P.-H., A.L.-M., J.-C.K., E.A.-P., S.V., M.Z., M.D.), NYU Grossman School of Medicine, NY.

Sarah Vermij (S)

Leon H Charney Division of Cardiology (M.P.-H., A.L.-M., J.-C.K., E.A.-P., S.V., M.Z., M.D.), NYU Grossman School of Medicine, NY.

Mingliang Zhang (M)

Leon H Charney Division of Cardiology (M.P.-H., A.L.-M., J.-C.K., E.A.-P., S.V., M.Z., M.D.), NYU Grossman School of Medicine, NY.

Feng-Xia Liang (FX)

Microscopy Laboratory, Division of Advanced Research Technologies. NYU Grossman School of Medicine, NY (F.-X.L.).

Paul Burridge (P)

Department of Pharmacology, Northwestern University Feinberg School of Medicine. Chicago, IL (M.J., P.B.).

David Fenyo (D)

Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology (S.K., D.F., E.R.), NYU Grossman School of Medicine, NY.

Eli Rothenberg (E)

Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology (S.K., D.F., E.R.), NYU Grossman School of Medicine, NY.

Mario Delmar (M)

Leon H Charney Division of Cardiology (M.P.-H., A.L.-M., J.-C.K., E.A.-P., S.V., M.Z., M.D.), NYU Grossman School of Medicine, NY.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Structural and Functional Characterization of a Na
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Structural and Functional Characterization of a Na
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Structural and Functional Characterization of a Na
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Structural and Functional Characterization of a Na
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural and Functional Characterization of a Na
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Structural and Functional Characterization of a Na
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Structural and Functional Characterization of a Na
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Microscopie électronique à balayage › Structural and Functional Characterization of a Na
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondries du muscle › Mitochondries du myocarde › Structural and Functional Characterization of a Na
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Structural and Functional Characterization of a Na
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Structural and Functional Characterization of a Na
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.5 › Structural and Functional Characterization of a Na
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Imagerie moléculaire › Imagerie de molécules uniques › Structural and Functional Characterization of a Na
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Antiports › Échangeur sodium-calcium › Structural and Functional Characterization of a Na
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Superoxydes › Structural and Functional Characterization of a Na