Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology.
Alzheimer’s disease
Amyloid-beta peptide
dendritic complexity
neuroglobin
resilience
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
05
2020
accepted:
28
08
2020
entrez:
21
12
2020
pubmed:
22
12
2020
medline:
22
12
2020
Statut:
epublish
Résumé
In humans, a considerable number of the autopsy samples of cognitively normal individuals aged between 57 and 102 years have revealed the presence of amyloid plaques, one of the typical signs of AD, indicating that many of us use mechanisms that defend ourselves from the toxic consequences of Aß. The human APP NL/F (hAPP NL/F) knockin mouse appears as the ideal mouse model to identify these mechanisms, since they have high Aß42 levels at an early age and moderate signs of disease when old. Here we show that in these mice, the brain levels of the hemoprotein Neuroglobin (Ngb) increase with age, in parallel with the increase in Aß42.
Identifiants
pubmed: 33343276
doi: 10.3389/fnins.2020.562581
pmc: PMC7744294
doi:
Types de publication
Journal Article
Langues
eng
Pagination
562581Informations de copyright
Copyright © 2020 de Vidania, Palomares-Perez, Frank-García, Saito, Saido, Draffin, Szaruga, Chávez-Gutierrez, Calero, Medina, Guix and Dotti.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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